Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Sang Youel Park, Timothy R. Billiar, Dai Wu Seol

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Hypoxia is a common environmental stress. Particularly, the center of rapidly growing solid tumors is easily exposed to hypoxic conditions. Thus, tumor cell response to hypoxia plays an important role in tumor progression as well as tumor therapy. However, little is known about hypoxic effect on apoptotic cell death. To examine the effects of hypoxia on TRAIL-induced apoptosis, human lung carcinoma A549 cells were exposed to hypoxia and treated with TRAIL protein. Hypoxia significantly protected A549 cells from apoptosis induced by TRAIL. Western blotting analysis demonstrated that hypoxia increased expression of antiapoptotic proteins such as Bcl-2, Bcl-XL, and IAP family members. The increase of these antiapoptotic molecules is believed to play an hypoxia-mediated protective role in TRAIL-induced apoptosis. Our findings suggest that an increase of antiapoptotic proteins induced by hypoxia may regulate the therapeutic activity of TRAIL protein in cancer therapy.

Original languageEnglish
Pages (from-to)150-153
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume291
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Apoptosis
  • Bcl-2
  • Hypoxia
  • TRAIL

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