Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities

Ting L. Luo, Christopher J. Harmer, Francois Lebreton, Jason Stam, Jason W. Bennett, Ruth M. Hall, Patrick T. Mc Gann*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

An outbreak involving an extensively antibiotic-resistant Acinetobacter baumannii strain in three military treatment facilities was identified. Fifty-nine isolates recovered from 30 patients over a 4-year period were found among a large collection of isolates using core genome multilocus sequence typing (MLST). They differed by only 0 to 18 single nucleotide polymorphisms (SNPs) and carried the same resistance determinants except that the aphA6 gene was missing in 25 isolates. They represent a novel sublineage of GC1 lineage 1 that likely originated in Afghanistan.

Original languageEnglish
JournalMicrobiology Spectrum
Volume11
Issue number3
DOIs
StatePublished - May 2023
Externally publishedYes

Keywords

  • AMR
  • Acinetobacter baumannii
  • GC1 lineage 1
  • antibiotic resistance
  • cgMLST
  • core genome MLST
  • epidemiology
  • microbial genomics
  • molecular epidemiology
  • outbreak
  • outbreak identification

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