Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities

Ting L. Luo; Christopher J. Harmer; Francois Lebreton; Jason Stam; Jason W. Bennett; Ruth M. Hall; Patrick T. Mc Gann

doi:10.1128/spectrum.00462-23

Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities

Ting L. Luo, Christopher J. Harmer, Francois Lebreton, Jason Stam, Jason W. Bennett, Ruth M. Hall, Patrick T. Mc Gann

Research output: Contribution to journal › Article › peer-review

Abstract

An outbreak involving an extensively antibiotic-resistant Acinetobacter baumannii strain in three military treatment facilities was identified. Fifty-nine isolates recovered from 30 patients over a 4-year period were found among a large collection of isolates using core genome multilocus sequence typing (MLST). They differed by only 0 to 18 single nucleotide polymorphisms (SNPs) and carried the same resistance determinants except that the aphA6 gene was missing in 25 isolates. They represent a novel sublineage of GC1 lineage 1 that likely originated in Afghanistan.

Original language	English
Journal	Microbiology Spectrum
Volume	11
Issue number	3
DOIs	https://doi.org/10.1128/spectrum.00462-23
State	Published - May 2023
Externally published	Yes

Keywords

AMR
Acinetobacter baumannii
GC1 lineage 1
antibiotic resistance
cgMLST
core genome MLST
epidemiology
microbial genomics
molecular epidemiology
outbreak
outbreak identification

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10.1128/spectrum.00462-23

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title = "Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities",

abstract = "An outbreak involving an extensively antibiotic-resistant Acinetobacter baumannii strain in three military treatment facilities was identified. Fifty-nine isolates recovered from 30 patients over a 4-year period were found among a large collection of isolates using core genome multilocus sequence typing (MLST). They differed by only 0 to 18 single nucleotide polymorphisms (SNPs) and carried the same resistance determinants except that the aphA6 gene was missing in 25 isolates. They represent a novel sublineage of GC1 lineage 1 that likely originated in Afghanistan.",

keywords = "AMR, Acinetobacter baumannii, GC1 lineage 1, antibiotic resistance, cgMLST, core genome MLST, epidemiology, microbial genomics, molecular epidemiology, outbreak, outbreak identification",

author = "Luo, {Ting L.} and Harmer, {Christopher J.} and Francois Lebreton and Jason Stam and Bennett, {Jason W.} and Hall, {Ruth M.} and {Mc Gann}, {Patrick T.}",

note = "Funding Information: C.J.H. and R.M.H. were supported by National Health and Medical Research Council (NHMRC) of Australia investigator grant GNT1194178 to R.M.H. MRSN funding was provided by Operation and Maintenance, Army (OMA). Publisher Copyright: {\textcopyright} 2023 Authors. All rights reserved.",

year = "2023",

month = may,

doi = "10.1128/spectrum.00462-23",

language = "English",

volume = "11",

journal = "Microbiology Spectrum",

issn = "2165-0497",

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AU - Luo, Ting L.

AU - Harmer, Christopher J.

AU - Lebreton, Francois

AU - Stam, Jason

AU - Bennett, Jason W.

AU - Hall, Ruth M.

AU - Mc Gann, Patrick T.

N1 - Funding Information: C.J.H. and R.M.H. were supported by National Health and Medical Research Council (NHMRC) of Australia investigator grant GNT1194178 to R.M.H. MRSN funding was provided by Operation and Maintenance, Army (OMA). Publisher Copyright: © 2023 Authors. All rights reserved.

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N2 - An outbreak involving an extensively antibiotic-resistant Acinetobacter baumannii strain in three military treatment facilities was identified. Fifty-nine isolates recovered from 30 patients over a 4-year period were found among a large collection of isolates using core genome multilocus sequence typing (MLST). They differed by only 0 to 18 single nucleotide polymorphisms (SNPs) and carried the same resistance determinants except that the aphA6 gene was missing in 25 isolates. They represent a novel sublineage of GC1 lineage 1 that likely originated in Afghanistan.

AB - An outbreak involving an extensively antibiotic-resistant Acinetobacter baumannii strain in three military treatment facilities was identified. Fifty-nine isolates recovered from 30 patients over a 4-year period were found among a large collection of isolates using core genome multilocus sequence typing (MLST). They differed by only 0 to 18 single nucleotide polymorphisms (SNPs) and carried the same resistance determinants except that the aphA6 gene was missing in 25 isolates. They represent a novel sublineage of GC1 lineage 1 that likely originated in Afghanistan.

KW - AMR

KW - Acinetobacter baumannii

KW - GC1 lineage 1

KW - antibiotic resistance

KW - cgMLST

KW - core genome MLST

KW - epidemiology

KW - microbial genomics

KW - molecular epidemiology

KW - outbreak

KW - outbreak identification

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JO - Microbiology Spectrum

JF - Microbiology Spectrum

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ER -

Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities

Abstract

Keywords

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