Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities

Ting L. Luo; Christopher J. Harmer; Francois Lebreton; Jason Stam; Jason W. Bennett; Ruth M. Hall; Patrick T. Mc Gann

doi:10.1128/spectrum.00462-23

Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities

Ting L. Luo, Christopher J. Harmer, Francois Lebreton, Jason Stam, Jason W. Bennett, Ruth M. Hall, Patrick T. Mc Gann^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An outbreak involving an extensively antibiotic-resistant Acinetobacter baumannii strain in three military treatment facilities was identified. Fifty-nine isolates recovered from 30 patients over a 4-year period were found among a large collection of isolates using core genome multilocus sequence typing (MLST). They differed by only 0 to 18 single nucleotide polymorphisms (SNPs) and carried the same resistance determinants except that the aphA6 gene was missing in 25 isolates. They represent a novel sublineage of GC1 lineage 1 that likely originated in Afghanistan.

Original language	English
Journal	Microbiology Spectrum
Volume	11
Issue number	3
DOIs	https://doi.org/10.1128/spectrum.00462-23
State	Published - May 2023
Externally published	Yes

Keywords

AMR
Acinetobacter baumannii
GC1 lineage 1
antibiotic resistance
cgMLST
core genome MLST
epidemiology
microbial genomics
molecular epidemiology
outbreak
outbreak identification

Access to Document

10.1128/spectrum.00462-23

Cite this

@article{90f0dbd19ace44358e99c76ae3d17dac,

title = "Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities",

abstract = "An outbreak involving an extensively antibiotic-resistant Acinetobacter baumannii strain in three military treatment facilities was identified. Fifty-nine isolates recovered from 30 patients over a 4-year period were found among a large collection of isolates using core genome multilocus sequence typing (MLST). They differed by only 0 to 18 single nucleotide polymorphisms (SNPs) and carried the same resistance determinants except that the aphA6 gene was missing in 25 isolates. They represent a novel sublineage of GC1 lineage 1 that likely originated in Afghanistan.",

keywords = "AMR, Acinetobacter baumannii, GC1 lineage 1, antibiotic resistance, cgMLST, core genome MLST, epidemiology, microbial genomics, molecular epidemiology, outbreak, outbreak identification",

author = "Luo, {Ting L.} and Harmer, {Christopher J.} and Francois Lebreton and Jason Stam and Bennett, {Jason W.} and Hall, {Ruth M.} and {Mc Gann}, {Patrick T.}",

year = "2023",

month = may,

doi = "10.1128/spectrum.00462-23",

language = "English",

volume = "11",

journal = "Microbiology Spectrum",

issn = "2165-0497",

number = "3",

}

TY - JOUR

T1 - Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities

AU - Luo, Ting L.

AU - Harmer, Christopher J.

AU - Lebreton, Francois

AU - Stam, Jason

AU - Bennett, Jason W.

AU - Hall, Ruth M.

AU - Mc Gann, Patrick T.

PY - 2023/5

Y1 - 2023/5

N2 - An outbreak involving an extensively antibiotic-resistant Acinetobacter baumannii strain in three military treatment facilities was identified. Fifty-nine isolates recovered from 30 patients over a 4-year period were found among a large collection of isolates using core genome multilocus sequence typing (MLST). They differed by only 0 to 18 single nucleotide polymorphisms (SNPs) and carried the same resistance determinants except that the aphA6 gene was missing in 25 isolates. They represent a novel sublineage of GC1 lineage 1 that likely originated in Afghanistan.

AB - An outbreak involving an extensively antibiotic-resistant Acinetobacter baumannii strain in three military treatment facilities was identified. Fifty-nine isolates recovered from 30 patients over a 4-year period were found among a large collection of isolates using core genome multilocus sequence typing (MLST). They differed by only 0 to 18 single nucleotide polymorphisms (SNPs) and carried the same resistance determinants except that the aphA6 gene was missing in 25 isolates. They represent a novel sublineage of GC1 lineage 1 that likely originated in Afghanistan.

KW - AMR

KW - Acinetobacter baumannii

KW - GC1 lineage 1

KW - antibiotic resistance

KW - cgMLST

KW - core genome MLST

KW - epidemiology

KW - microbial genomics

KW - molecular epidemiology

KW - outbreak

KW - outbreak identification

UR - http://www.scopus.com/inward/record.url?scp=85163913602&partnerID=8YFLogxK

U2 - 10.1128/spectrum.00462-23

DO - 10.1128/spectrum.00462-23

M3 - Article

C2 - 37140387

AN - SCOPUS:85163913602

SN - 2165-0497

VL - 11

JO - Microbiology Spectrum

JF - Microbiology Spectrum

IS - 3

ER -

Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities

Abstract

Keywords

Access to Document

Fingerprint

Cite this