Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer

Tristan M. Sissung; John Deeken; Crystal R. Leibrand; Douglas K. Price; Sheryl Ehrlich; Seth M. Steinberg; David J. Liewehr; William Dahut; William D. Figg

doi:10.2217/pgs-2016-0134

Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer

Tristan M. Sissung^*, John Deeken, Crystal R. Leibrand, Douglas K. Price, Sheryl Ehrlich, Seth M. Steinberg, David J. Liewehr, William Dahut, William D. Figg

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Aim: Metabolism and transport play major roles in life-long exposure to endogenous and exogenous carcinogens. We therefore explored associations between polymorphisms in absorption, distribution, metabolism and elimination genes and the risk and prognosis of castration-resistant prostate cancer (CRPC). Materials & methods: A total of 634 genotypes were tested in 74 patients using the Affymetrix DMETv1.0 platform. Results: No relation to risk was found. Three SNPs were associated with CRPC prognosis in Caucasians: ABCB11 rs7602171G>A (p = 0.003; n = 30; hazard ratio [HR]: 0.307), GSTP1 rs1799811C>T (p = 0.001; n = 38; HR: 0.254) and SLC5A6 rs1395 (p = 0.004; n = 35; HR: 3.15). Two other polymorphisms among Caucasians were associated with interesting trends: ABCB4 rs2302387C>T (p = 0.039) and ABCC5 rs939339A>G (p = 0.018). Conclusion: This exploratory study is the first to show that polymorphisms in several absorption, distribution, metabolism and elimination genes may be associated with CRPC prognosis.

Original language	English
Pages (from-to)	1979-1986
Number of pages	8
Journal	Pharmacogenomics
Volume	17
Issue number	18
DOIs	https://doi.org/10.2217/pgs-2016-0134
State	Published - Dec 2016
Externally published	Yes

Keywords

castration-resistant prostate cancer
genotype
metabolism
outcome
survival
transport

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@article{777874ce265843f9a1f04ae811ec2be3,

title = "Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer",

abstract = "Aim: Metabolism and transport play major roles in life-long exposure to endogenous and exogenous carcinogens. We therefore explored associations between polymorphisms in absorption, distribution, metabolism and elimination genes and the risk and prognosis of castration-resistant prostate cancer (CRPC). Materials & methods: A total of 634 genotypes were tested in 74 patients using the Affymetrix DMETv1.0 platform. Results: No relation to risk was found. Three SNPs were associated with CRPC prognosis in Caucasians: ABCB11 rs7602171G>A (p = 0.003; n = 30; hazard ratio [HR]: 0.307), GSTP1 rs1799811C>T (p = 0.001; n = 38; HR: 0.254) and SLC5A6 rs1395 (p = 0.004; n = 35; HR: 3.15). Two other polymorphisms among Caucasians were associated with interesting trends: ABCB4 rs2302387C>T (p = 0.039) and ABCC5 rs939339A>G (p = 0.018). Conclusion: This exploratory study is the first to show that polymorphisms in several absorption, distribution, metabolism and elimination genes may be associated with CRPC prognosis.",

keywords = "castration-resistant prostate cancer, genotype, metabolism, outcome, survival, transport",

author = "Sissung, {Tristan M.} and John Deeken and Leibrand, {Crystal R.} and Price, {Douglas K.} and Sheryl Ehrlich and Steinberg, {Seth M.} and Liewehr, {David J.} and William Dahut and Figg, {William D.}",

note = "Publisher Copyright: {\textcopyright} 2016 Future Medicine Ltd.",

year = "2016",

month = dec,

doi = "10.2217/pgs-2016-0134",

language = "English",

volume = "17",

pages = "1979--1986",

journal = "Pharmacogenomics",

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TY - JOUR

T1 - Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer

AU - Sissung, Tristan M.

AU - Deeken, John

AU - Leibrand, Crystal R.

AU - Price, Douglas K.

AU - Ehrlich, Sheryl

AU - Steinberg, Seth M.

AU - Liewehr, David J.

AU - Dahut, William

AU - Figg, William D.

PY - 2016/12

Y1 - 2016/12

N2 - Aim: Metabolism and transport play major roles in life-long exposure to endogenous and exogenous carcinogens. We therefore explored associations between polymorphisms in absorption, distribution, metabolism and elimination genes and the risk and prognosis of castration-resistant prostate cancer (CRPC). Materials & methods: A total of 634 genotypes were tested in 74 patients using the Affymetrix DMETv1.0 platform. Results: No relation to risk was found. Three SNPs were associated with CRPC prognosis in Caucasians: ABCB11 rs7602171G>A (p = 0.003; n = 30; hazard ratio [HR]: 0.307), GSTP1 rs1799811C>T (p = 0.001; n = 38; HR: 0.254) and SLC5A6 rs1395 (p = 0.004; n = 35; HR: 3.15). Two other polymorphisms among Caucasians were associated with interesting trends: ABCB4 rs2302387C>T (p = 0.039) and ABCC5 rs939339A>G (p = 0.018). Conclusion: This exploratory study is the first to show that polymorphisms in several absorption, distribution, metabolism and elimination genes may be associated with CRPC prognosis.

AB - Aim: Metabolism and transport play major roles in life-long exposure to endogenous and exogenous carcinogens. We therefore explored associations between polymorphisms in absorption, distribution, metabolism and elimination genes and the risk and prognosis of castration-resistant prostate cancer (CRPC). Materials & methods: A total of 634 genotypes were tested in 74 patients using the Affymetrix DMETv1.0 platform. Results: No relation to risk was found. Three SNPs were associated with CRPC prognosis in Caucasians: ABCB11 rs7602171G>A (p = 0.003; n = 30; hazard ratio [HR]: 0.307), GSTP1 rs1799811C>T (p = 0.001; n = 38; HR: 0.254) and SLC5A6 rs1395 (p = 0.004; n = 35; HR: 3.15). Two other polymorphisms among Caucasians were associated with interesting trends: ABCB4 rs2302387C>T (p = 0.039) and ABCC5 rs939339A>G (p = 0.018). Conclusion: This exploratory study is the first to show that polymorphisms in several absorption, distribution, metabolism and elimination genes may be associated with CRPC prognosis.

KW - castration-resistant prostate cancer

KW - genotype

KW - metabolism

KW - outcome

KW - survival

KW - transport

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U2 - 10.2217/pgs-2016-0134

DO - 10.2217/pgs-2016-0134

M3 - Article

C2 - 27883295

AN - SCOPUS:85002721802

SN - 1462-2416

VL - 17

SP - 1979

EP - 1986

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 18

ER -

Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer

Abstract

Keywords

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