TY - JOUR
T1 - IL-17A – A regulator in acute inflammation
T2 - Insights from in vitro, in vivo and in silico studies
AU - Sud, Vikas
AU - Abboud, Andrew
AU - Tohme, Samer
AU - Vodovotz, Yoram
AU - Simmons, Richard L.
AU - Tsung, Allan
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2021/3
Y1 - 2021/3
N2 - Acute inflammation following sterile injury is both inevitable and necessary to restore homeostasis and promote tissue repair. However, when excessive, inflammation can jeopardize the viability of organs and cause detrimental systemic effects. Identifying key-regulators of the immune cascade induced by surgery is vital to attenuating excessive inflammation and its subsequent effects. In this review, we describe the emerging role of IL-17A as a key-regulator in acute inflammation. The role of IL-17A in chronic disease states, such as rheumatoid arthritis, psoriasis and cancer has been well documented, but its significance in acute inflammation following surgery, sepsis, or traumatic injury has not been well studied. We aim to highlight the role of IL-17A in acute inflammation caused by trauma, liver ischemia, and organ transplantation, as well as in post-operative surgical infections. Further investigation of the roles of this cytokine in acute inflammation may stimulate novel therapies or diagnostic modalities.
AB - Acute inflammation following sterile injury is both inevitable and necessary to restore homeostasis and promote tissue repair. However, when excessive, inflammation can jeopardize the viability of organs and cause detrimental systemic effects. Identifying key-regulators of the immune cascade induced by surgery is vital to attenuating excessive inflammation and its subsequent effects. In this review, we describe the emerging role of IL-17A as a key-regulator in acute inflammation. The role of IL-17A in chronic disease states, such as rheumatoid arthritis, psoriasis and cancer has been well documented, but its significance in acute inflammation following surgery, sepsis, or traumatic injury has not been well studied. We aim to highlight the role of IL-17A in acute inflammation caused by trauma, liver ischemia, and organ transplantation, as well as in post-operative surgical infections. Further investigation of the roles of this cytokine in acute inflammation may stimulate novel therapies or diagnostic modalities.
KW - Acute inflammation
KW - Computational modeling
KW - IL-17A
UR - http://www.scopus.com/inward/record.url?scp=85048987030&partnerID=8YFLogxK
U2 - 10.1016/j.cyto.2018.03.030
DO - 10.1016/j.cyto.2018.03.030
M3 - Review article
C2 - 29954675
AN - SCOPUS:85048987030
SN - 1043-4666
VL - 139
JO - Cytokine
JF - Cytokine
M1 - 154344
ER -