Immune activation in the liver by nucleic acids

Qian Sun, Qingde Wang, Melanie J. Scott, Timothy R. Billiar*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Viral infection in the liver, including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, is a major health problem worldwide, especially in developing countries. The infection triggers a pro-inflammatory response in patients that is crucial for host defense. Recent studies have identified multiple transmembrane and cytosolic receptors that recog-nize pathogen-derived nucleic acids, and these receptors are essential for driving immune activation in the liver. In addition to sensing DNA/RNA from pathogens, these intracellular receptors can be activated by nucleic acids of host origin in response to sterile injuries. In this review, we discuss the expanding roles of these receptors in both immune and nonimmune cells in the liver.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalJournal of Clinical and Translational Hepatology
Volume4
Issue number2
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • Hepatocytes
  • Innate immunity
  • Intracellular receptor
  • Nucleic acid

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