Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection

Emilie Goguet; Cara H. Olsen; William A. Meyer; Sara Ansari; John H. Powers; Tonia L. Conner; Si’Ana A. Coggins; Wei Wang; Richard Wang; Luca Illinik; Margaret Sanchez Edwards; Belinda M. Jackson-Thompson; Monique Hollis-Perry; Gregory Wang; Yolanda Alcorta; Mimi A. Wong; David Saunders; Roshila Mohammed; Bolatito Balogun; Priscilla Kobi; Lakeesha Kosh; Kimberly Bishop-Lilly; Regina Z. Cer; Catherine E. Arnold; Logan J. Voegtly; Maren Fitzpatrick; Andrea E. Luquette; Francisco Malagon; Orlando Ortega; Edward Parmelee; Julian Davies; Alyssa R. Lindrose; Hannah Haines-Hull; Matthew S. Moser; Emily C. Samuels; Marana S. Rekedal; Elizabeth K. Graydon; Allison M.W. Malloy; David R Tribble; Timothy H. Burgess; Wesley Campbell; Sara Robinson; Christopher C. Broder; Robert J. O’Connell; Carol D. Weiss; Simon Pollett; Eric D Laing; Edward Mitre

doi:10.3389/fimmu.2024.1287504

Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection

Emilie Goguet^*, Cara H. Olsen, William A. Meyer, Sara Ansari, John H. Powers, Tonia L. Conner, Si’Ana A. Coggins, Wei Wang, Richard Wang, Luca Illinik, Margaret Sanchez Edwards, Belinda M. Jackson-Thompson, Monique Hollis-Perry, Gregory Wang, Yolanda Alcorta, Mimi A. Wong, David Saunders, Roshila Mohammed, Bolatito Balogun, Priscilla KobiLakeesha Kosh, Kimberly Bishop-Lilly, Regina Z. Cer, Catherine E. Arnold, Logan J. Voegtly, Maren Fitzpatrick, Andrea E. Luquette, Francisco Malagon, Orlando Ortega, Edward Parmelee, Julian Davies, Alyssa R. Lindrose, Hannah Haines-Hull, Matthew S. Moser, Emily C. Samuels, Marana S. Rekedal, Elizabeth K. Graydon, Allison M.W. Malloy, David R Tribble, Timothy H. Burgess, Wesley Campbell, Sara Robinson, Christopher C. Broder, Robert J. O’Connell, Carol D. Weiss, Simon Pollett, Eric D Laing, Edward Mitre^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Introduction: We sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in the United States. Methods: Serum and saliva samples from 176 vaccinated adults were collected from October to December of 2021, immediately before the Omicron wave, and assessed for SARS-CoV-2 Spike-specific IgG and IgA binding antibodies (bAb). Sera were also assessed for bAb using commercial assays, and for neutralization activity against several SARS-CoV-2 variants. PVI duration and severity, as well as risk and precautionary behaviors, were assessed by questionnaires. Results: Serum anti-Spike IgG levels assessed by research assay, neutralization titers against Omicron subvariants, and low home risk scores correlated with protection against PVIs after multivariable regression analysis. Commercial assays did not perform as well as research assay, likely due to their lower dynamic range. Discussion: In the 32 participants that developed PVI, anti-Spike IgG bAbs correlated with lower disease severity and shorter duration of illness.

Original language	English
Article number	1287504
Journal	Frontiers in Immunology
Volume	15
DOIs	https://doi.org/10.3389/fimmu.2024.1287504
State	Published - 2024
Externally published	Yes

Keywords

COVID-19
SARS-CoV-2
correlates of immunity
respiratory infection
vaccination

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10.3389/fimmu.2024.1287504

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Goguet, E., Olsen, C. H., Meyer, W. A., Ansari, S., Powers, J. H., Conner, T. L., Coggins, SA. A., Wang, W., Wang, R., Illinik, L., Sanchez Edwards, M., Jackson-Thompson, B. M., Hollis-Perry, M., Wang, G., Alcorta, Y., Wong, M. A., Saunders, D., Mohammed, R., Balogun, B., ... Mitre, E. (2024). Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection. Frontiers in Immunology, 15, Article 1287504. https://doi.org/10.3389/fimmu.2024.1287504

@article{bbb1ca57242c424786df2bbf0b6739da,

title = "Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection",

abstract = "Introduction: We sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in the United States. Methods: Serum and saliva samples from 176 vaccinated adults were collected from October to December of 2021, immediately before the Omicron wave, and assessed for SARS-CoV-2 Spike-specific IgG and IgA binding antibodies (bAb). Sera were also assessed for bAb using commercial assays, and for neutralization activity against several SARS-CoV-2 variants. PVI duration and severity, as well as risk and precautionary behaviors, were assessed by questionnaires. Results: Serum anti-Spike IgG levels assessed by research assay, neutralization titers against Omicron subvariants, and low home risk scores correlated with protection against PVIs after multivariable regression analysis. Commercial assays did not perform as well as research assay, likely due to their lower dynamic range. Discussion: In the 32 participants that developed PVI, anti-Spike IgG bAbs correlated with lower disease severity and shorter duration of illness.",

keywords = "COVID-19, SARS-CoV-2, correlates of immunity, respiratory infection, vaccination",

author = "Emilie Goguet and Olsen, {Cara H.} and Meyer, {William A.} and Sara Ansari and Powers, {John H.} and Conner, {Tonia L.} and Coggins, {Si{\textquoteright}Ana A.} and Wei Wang and Richard Wang and Luca Illinik and {Sanchez Edwards}, Margaret and Jackson-Thompson, {Belinda M.} and Monique Hollis-Perry and Gregory Wang and Yolanda Alcorta and Wong, {Mimi A.} and David Saunders and Roshila Mohammed and Bolatito Balogun and Priscilla Kobi and Lakeesha Kosh and Kimberly Bishop-Lilly and Cer, {Regina Z.} and Arnold, {Catherine E.} and Voegtly, {Logan J.} and Maren Fitzpatrick and Luquette, {Andrea E.} and Francisco Malagon and Orlando Ortega and Edward Parmelee and Julian Davies and Lindrose, {Alyssa R.} and Hannah Haines-Hull and Moser, {Matthew S.} and Samuels, {Emily C.} and Rekedal, {Marana S.} and Graydon, {Elizabeth K.} and Malloy, {Allison M.W.} and David R Tribble and Burgess, {Timothy H.} and Wesley Campbell and Sara Robinson and Broder, {Christopher C.} and O{\textquoteright}Connell, {Robert J.} and Weiss, {Carol D.} and Simon Pollett and Eric D Laing and Edward Mitre",

note = "Publisher Copyright: Copyright {\textcopyright} 2024 Goguet, Olsen, Meyer, Ansari, Powers, Conner, Coggins, Wang, Wang, Illinik, Sanchez Edwards, Jackson-Thompson, Hollis-Perry, Wang, Alcorta, Wong, Saunders, Mohammed, Balogun, Kobi, Kosh, Bishop-Lilly, Cer, Arnold, Voegtly, Fitzpatrick, Luquette, Malagon, Ortega, Parmelee, Davies, Lindrose, Haines-Hull, Moser, Samuels, Rekedal, Graydon, Malloy, Tribble, Burgess, Campbell, Robinson, Broder, O{\textquoteright}Connell, Weiss, Pollett, Laing and Mitre.",

year = "2024",

doi = "10.3389/fimmu.2024.1287504",

language = "English",

volume = "15",

journal = "Frontiers in Immunology",

issn = "1664-3224",

}

Goguet, E, Olsen, CH, Meyer, WA, Ansari, S, Powers, JH, Conner, TL, Coggins, SAA, Wang, W, Wang, R, Illinik, L, Sanchez Edwards, M, Jackson-Thompson, BM, Hollis-Perry, M, Wang, G, Alcorta, Y, Wong, MA, Saunders, D, Mohammed, R, Balogun, B, Kobi, P, Kosh, L, Bishop-Lilly, K, Cer, RZ, Arnold, CE, Voegtly, LJ, Fitzpatrick, M, Luquette, AE, Malagon, F, Ortega, O, Parmelee, E, Davies, J, Lindrose, AR, Haines-Hull, H, Moser, MS, Samuels, EC, Rekedal, MS, Graydon, EK, Malloy, AMW, Tribble, DR , Burgess, TH, Campbell, W, Robinson, S, Broder, CC, O’Connell, RJ, Weiss, CD, Pollett, S, Laing, ED & Mitre, E 2024, 'Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection', Frontiers in Immunology, vol. 15, 1287504. https://doi.org/10.3389/fimmu.2024.1287504

TY - JOUR

T1 - Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection

AU - Goguet, Emilie

AU - Olsen, Cara H.

AU - Meyer, William A.

AU - Ansari, Sara

AU - Powers, John H.

AU - Conner, Tonia L.

AU - Coggins, Si’Ana A.

AU - Wang, Wei

AU - Wang, Richard

AU - Illinik, Luca

AU - Sanchez Edwards, Margaret

AU - Jackson-Thompson, Belinda M.

AU - Hollis-Perry, Monique

AU - Wang, Gregory

AU - Alcorta, Yolanda

AU - Wong, Mimi A.

AU - Saunders, David

AU - Mohammed, Roshila

AU - Balogun, Bolatito

AU - Kobi, Priscilla

AU - Kosh, Lakeesha

AU - Bishop-Lilly, Kimberly

AU - Cer, Regina Z.

AU - Arnold, Catherine E.

AU - Voegtly, Logan J.

AU - Fitzpatrick, Maren

AU - Luquette, Andrea E.

AU - Malagon, Francisco

AU - Ortega, Orlando

AU - Parmelee, Edward

AU - Davies, Julian

AU - Lindrose, Alyssa R.

AU - Haines-Hull, Hannah

AU - Moser, Matthew S.

AU - Samuels, Emily C.

AU - Rekedal, Marana S.

AU - Graydon, Elizabeth K.

AU - Malloy, Allison M.W.

AU - Tribble, David R

AU - Burgess, Timothy H.

AU - Campbell, Wesley

AU - Robinson, Sara

AU - Broder, Christopher C.

AU - O’Connell, Robert J.

AU - Weiss, Carol D.

AU - Pollett, Simon

AU - Laing, Eric D

AU - Mitre, Edward

N1 - Publisher Copyright: Copyright © 2024 Goguet, Olsen, Meyer, Ansari, Powers, Conner, Coggins, Wang, Wang, Illinik, Sanchez Edwards, Jackson-Thompson, Hollis-Perry, Wang, Alcorta, Wong, Saunders, Mohammed, Balogun, Kobi, Kosh, Bishop-Lilly, Cer, Arnold, Voegtly, Fitzpatrick, Luquette, Malagon, Ortega, Parmelee, Davies, Lindrose, Haines-Hull, Moser, Samuels, Rekedal, Graydon, Malloy, Tribble, Burgess, Campbell, Robinson, Broder, O’Connell, Weiss, Pollett, Laing and Mitre.

PY - 2024

Y1 - 2024

N2 - Introduction: We sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in the United States. Methods: Serum and saliva samples from 176 vaccinated adults were collected from October to December of 2021, immediately before the Omicron wave, and assessed for SARS-CoV-2 Spike-specific IgG and IgA binding antibodies (bAb). Sera were also assessed for bAb using commercial assays, and for neutralization activity against several SARS-CoV-2 variants. PVI duration and severity, as well as risk and precautionary behaviors, were assessed by questionnaires. Results: Serum anti-Spike IgG levels assessed by research assay, neutralization titers against Omicron subvariants, and low home risk scores correlated with protection against PVIs after multivariable regression analysis. Commercial assays did not perform as well as research assay, likely due to their lower dynamic range. Discussion: In the 32 participants that developed PVI, anti-Spike IgG bAbs correlated with lower disease severity and shorter duration of illness.

AB - Introduction: We sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in the United States. Methods: Serum and saliva samples from 176 vaccinated adults were collected from October to December of 2021, immediately before the Omicron wave, and assessed for SARS-CoV-2 Spike-specific IgG and IgA binding antibodies (bAb). Sera were also assessed for bAb using commercial assays, and for neutralization activity against several SARS-CoV-2 variants. PVI duration and severity, as well as risk and precautionary behaviors, were assessed by questionnaires. Results: Serum anti-Spike IgG levels assessed by research assay, neutralization titers against Omicron subvariants, and low home risk scores correlated with protection against PVIs after multivariable regression analysis. Commercial assays did not perform as well as research assay, likely due to their lower dynamic range. Discussion: In the 32 participants that developed PVI, anti-Spike IgG bAbs correlated with lower disease severity and shorter duration of illness.

KW - COVID-19

KW - SARS-CoV-2

KW - correlates of immunity

KW - respiratory infection

KW - vaccination

UR - http://www.scopus.com/inward/record.url?scp=85189183786&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2024.1287504

DO - 10.3389/fimmu.2024.1287504

M3 - Article

C2 - 38566991

AN - SCOPUS:85189183786

SN - 1664-3224

VL - 15

JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 1287504

ER -

Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection

Abstract

Keywords

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