Immune regulation of procalcitonin: Abiomarker and mediator of infection

G. N. Matwiyoff, J. D. Prahl, R. J. Miller, J. J. Carmichael, D. E. Amundson, G. Seda, M. Daheshia*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations

Abstract

Procalcitonin (PCT) has recently emerged as a powerful biomarker for an early and accurate diagnosis of bacterial infection. Here we summarize our current understanding of the expression pathways of PCT, its potential cellular sources including immune cells, and factors inducing its secretion. Also addressed is the significance of increased blood PCT concentration, which may allow this molecule not only to act as a clinical biomarker but also as an active participant in the development and progression of infectious processes. Experimental approaches to delineate a better understanding of PCT functions, molecular pathways that modulate its expression and therapeutic opportunities to curtail its biological actions are discussed, as well. copyright

Original languageEnglish
Pages (from-to)401-409
Number of pages9
JournalInflammation Research
Volume61
Issue number5
DOIs
StatePublished - May 2012
Externally publishedYes

Keywords

  • Biomarker
  • Infection
  • Inflammation
  • Procalcitonin
  • Regulation

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