Immune regulation of procalcitonin: Abiomarker and mediator of infection

G. N. Matwiyoff; J. D. Prahl; R. J. Miller; J. J. Carmichael; D. E. Amundson; G. Seda; M. Daheshia

doi:10.1007/s00011-012-0439-5

Immune regulation of procalcitonin: Abiomarker and mediator of infection

G. N. Matwiyoff, J. D. Prahl, R. J. Miller, J. J. Carmichael, D. E. Amundson, G. Seda, M. Daheshia^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

Procalcitonin (PCT) has recently emerged as a powerful biomarker for an early and accurate diagnosis of bacterial infection. Here we summarize our current understanding of the expression pathways of PCT, its potential cellular sources including immune cells, and factors inducing its secretion. Also addressed is the significance of increased blood PCT concentration, which may allow this molecule not only to act as a clinical biomarker but also as an active participant in the development and progression of infectious processes. Experimental approaches to delineate a better understanding of PCT functions, molecular pathways that modulate its expression and therapeutic opportunities to curtail its biological actions are discussed, as well. copyright

Original language	English
Pages (from-to)	401-409
Number of pages	9
Journal	Inflammation Research
Volume	61
Issue number	5
DOIs	https://doi.org/10.1007/s00011-012-0439-5
State	Published - May 2012
Externally published	Yes

Keywords

Biomarker
Infection
Inflammation
Procalcitonin
Regulation

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10.1007/s00011-012-0439-5

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title = "Immune regulation of procalcitonin: Abiomarker and mediator of infection",

abstract = "Procalcitonin (PCT) has recently emerged as a powerful biomarker for an early and accurate diagnosis of bacterial infection. Here we summarize our current understanding of the expression pathways of PCT, its potential cellular sources including immune cells, and factors inducing its secretion. Also addressed is the significance of increased blood PCT concentration, which may allow this molecule not only to act as a clinical biomarker but also as an active participant in the development and progression of infectious processes. Experimental approaches to delineate a better understanding of PCT functions, molecular pathways that modulate its expression and therapeutic opportunities to curtail its biological actions are discussed, as well. copyright",

keywords = "Biomarker, Infection, Inflammation, Procalcitonin, Regulation",

author = "Matwiyoff, {G. N.} and Prahl, {J. D.} and Miller, {R. J.} and Carmichael, {J. J.} and Amundson, {D. E.} and G. Seda and M. Daheshia",

year = "2012",

month = may,

doi = "10.1007/s00011-012-0439-5",

language = "English",

volume = "61",

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journal = "Inflammation Research",

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T1 - Immune regulation of procalcitonin

T2 - Abiomarker and mediator of infection

AU - Matwiyoff, G. N.

AU - Prahl, J. D.

AU - Miller, R. J.

AU - Carmichael, J. J.

AU - Amundson, D. E.

AU - Seda, G.

AU - Daheshia, M.

PY - 2012/5

Y1 - 2012/5

N2 - Procalcitonin (PCT) has recently emerged as a powerful biomarker for an early and accurate diagnosis of bacterial infection. Here we summarize our current understanding of the expression pathways of PCT, its potential cellular sources including immune cells, and factors inducing its secretion. Also addressed is the significance of increased blood PCT concentration, which may allow this molecule not only to act as a clinical biomarker but also as an active participant in the development and progression of infectious processes. Experimental approaches to delineate a better understanding of PCT functions, molecular pathways that modulate its expression and therapeutic opportunities to curtail its biological actions are discussed, as well. copyright

AB - Procalcitonin (PCT) has recently emerged as a powerful biomarker for an early and accurate diagnosis of bacterial infection. Here we summarize our current understanding of the expression pathways of PCT, its potential cellular sources including immune cells, and factors inducing its secretion. Also addressed is the significance of increased blood PCT concentration, which may allow this molecule not only to act as a clinical biomarker but also as an active participant in the development and progression of infectious processes. Experimental approaches to delineate a better understanding of PCT functions, molecular pathways that modulate its expression and therapeutic opportunities to curtail its biological actions are discussed, as well. copyright

KW - Biomarker

KW - Infection

KW - Inflammation

KW - Procalcitonin

KW - Regulation

UR - http://www.scopus.com/inward/record.url?scp=84863113328&partnerID=8YFLogxK

U2 - 10.1007/s00011-012-0439-5

DO - 10.1007/s00011-012-0439-5

M3 - Review article

C2 - 22354317

AN - SCOPUS:84863113328

SN - 1023-3830

VL - 61

SP - 401

EP - 409

JO - Inflammation Research

JF - Inflammation Research

IS - 5

ER -

Immune regulation of procalcitonin: Abiomarker and mediator of infection

Abstract

Keywords

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