Immune response to biologic scaffold materials

Stephen F. Badylak*, Thomas W. Gilbert

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

730 Scopus citations


Biologic scaffold materials composed of mammalian extracellular matrix are commonly used in regenerative medicine and in surgical procedures for the reconstruction of numerous tissue and organs. These biologic materials are typically allogeneic or xenogeneic in origin and are derived from tissues such as small intestine, urinary bladder, dermis, and pericardium. The innate and acquired host immune response to these biologic materials and the effect of the immune response upon downstream remodeling events has been largely unexplored. Variables that affect the host response include manufacturing processes, the rate of scaffold degradation, and the presence of cross species antigens. This manuscript provides an overview of studies that have evaluated the immune response to biologic scaffold materials and variables that affect this response.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalSeminars in Immunology
Issue number2
StatePublished - Apr 2008
Externally publishedYes


  • Extracellular matrix
  • Regenerative medicine
  • Remodeling
  • Scaffold


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