Immunogenicity of a psoralen-inactivated dengue virus type 1 vaccine candidate in mice

Ryan C. Maves; Roger M. Castillo Oré; Kevin R. Porter; Tadeusz J. Kochel

doi:10.1128/CVI.00353-09

Immunogenicity of a psoralen-inactivated dengue virus type 1 vaccine candidate in mice

Ryan C. Maves, Roger M. Castillo Oré, Kevin R. Porter, Tadeusz J. Kochel

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18 Scopus citations

Abstract

We evaluated a novel psoralen-inactivated dengue virus type 1 (DENV-1) vaccine candidate in Mus musculus mice. Mice received intradermal alum or 5 to 10 ng of psoralen-inactivated virus. Anti-DENV-1 neutralizing antibody was detectable in 10/11 mice receiving a 10-ng dose at 90 days. Psoralen-inactivated DENV-1 is immunogenic in mice.

Original language	English
Pages (from-to)	304-306
Number of pages	3
Journal	Clinical and Vaccine Immunology
Volume	17
Issue number	2
DOIs	https://doi.org/10.1128/CVI.00353-09
State	Published - Feb 2010
Externally published	Yes

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abstract = "We evaluated a novel psoralen-inactivated dengue virus type 1 (DENV-1) vaccine candidate in Mus musculus mice. Mice received intradermal alum or 5 to 10 ng of psoralen-inactivated virus. Anti-DENV-1 neutralizing antibody was detectable in 10/11 mice receiving a 10-ng dose at 90 days. Psoralen-inactivated DENV-1 is immunogenic in mice.",

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Immunogenicity of a psoralen-inactivated dengue virus type 1 vaccine candidate in mice

Abstract

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