Immunology of protection from Ebola virus infection

Philip R. Krause; Paula R. Bryant; Thomas Clark; Walla Dempsey; Erik Henchal; Nelson L. Michael; Jason A. Regules; Marion F. Gruber

doi:10.1126/scitranslmed.aaa8202

Immunology of protection from Ebola virus infection

Philip R. Krause^*, Paula R. Bryant, Thomas Clark, Walla Dempsey, Erik Henchal, Nelson L. Michael, Jason A. Regules, Marion F. Gruber

^*Corresponding author for this work

Medicine

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

A December 2014 meeting reviewed Ebola virus immunology relevant to vaccine development, including Ebola prevention, immunity, assay standardization, and regulatory considerations. Vaccinated humans appear to achieve immune responses comparable in magnitude with those associated with protection in nonhuman primates, suggesting that immunological data could be used to demonstrate vaccine efficacy.

Original language	English
Journal	Science Translational Medicine
Volume	7
Issue number	286
DOIs	https://doi.org/10.1126/scitranslmed.aaa8202
State	Published - 6 May 2015

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@article{747f8c3cae5f439ea14af57e34f9e467,

title = "Immunology of protection from Ebola virus infection",

abstract = "A December 2014 meeting reviewed Ebola virus immunology relevant to vaccine development, including Ebola prevention, immunity, assay standardization, and regulatory considerations. Vaccinated humans appear to achieve immune responses comparable in magnitude with those associated with protection in nonhuman primates, suggesting that immunological data could be used to demonstrate vaccine efficacy.",

author = "Krause, {Philip R.} and Bryant, {Paula R.} and Thomas Clark and Walla Dempsey and Erik Henchal and Michael, {Nelson L.} and Regules, {Jason A.} and Gruber, {Marion F.}",

year = "2015",

month = may,

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doi = "10.1126/scitranslmed.aaa8202",

language = "English",

volume = "7",

journal = "Science Translational Medicine",

issn = "1946-6234",

publisher = "American Association for the Advancement of Science",

number = "286",

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AU - Krause, Philip R.

AU - Bryant, Paula R.

AU - Clark, Thomas

AU - Dempsey, Walla

AU - Henchal, Erik

AU - Michael, Nelson L.

AU - Regules, Jason A.

AU - Gruber, Marion F.

PY - 2015/5/6

Y1 - 2015/5/6

N2 - A December 2014 meeting reviewed Ebola virus immunology relevant to vaccine development, including Ebola prevention, immunity, assay standardization, and regulatory considerations. Vaccinated humans appear to achieve immune responses comparable in magnitude with those associated with protection in nonhuman primates, suggesting that immunological data could be used to demonstrate vaccine efficacy.

AB - A December 2014 meeting reviewed Ebola virus immunology relevant to vaccine development, including Ebola prevention, immunity, assay standardization, and regulatory considerations. Vaccinated humans appear to achieve immune responses comparable in magnitude with those associated with protection in nonhuman primates, suggesting that immunological data could be used to demonstrate vaccine efficacy.

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U2 - 10.1126/scitranslmed.aaa8202

DO - 10.1126/scitranslmed.aaa8202

M3 - Review article

C2 - 25947159

AN - SCOPUS:84928958002

SN - 1946-6234

VL - 7

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 286

ER -

Immunology of protection from Ebola virus infection

Abstract

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