TY - JOUR
T1 - Improvement in cerebral function with treatment of posttraumatic stress disorder
AU - Roy, Michael J.
AU - Francis, Jennifer
AU - Friedlander, Joshua
AU - Banks-Williams, Lisa
AU - Lande, Raymond G.
AU - Taylor, Patricia
AU - Blair, James
AU - Mclellan, Jennifer
AU - Law, Wendy
AU - Tarpley, Vanita
AU - Patt, Ivy
AU - Yu, Henry
AU - Mallinger, Alan
AU - Difede, Joann
AU - Rizzo, Albert
AU - Rothbaum, Barbara
PY - 2010/10
Y1 - 2010/10
N2 - Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are signature illnesses of the Iraq and Afghanistan wars, but current diagnostic and therapeutic measures for these conditions are suboptimal. In our study, functional magnetic resonance imaging (fMRI) is used to try to differentiate military service members with: PTSD and mTBI, PTSD alone, mTBI alone, and neither PTSD nor mTBI. Those with PTSD are then randomized to virtual reality exposure therapy or imaginal exposure. fMRI is repeated after treatment and along with the Clinician-Administered PTSD Scale (CAPS) and Clinical Global Impression (CGI) scores to compare with baseline. Twenty subjects have completed baseline fMRI scans, including four controls and one mTBI only; of 15 treated for PTSD, eight completed posttreatment scans. Most subjects have been male (93%) and Caucasian (83%), with a mean age of 34. Significant improvements are evident on fMRI scans, and corroborated by CGI scores, but CAPS scores improvements are modest. In conclusion, CGI scores and fMRI scans indicate significant improvement in PTSD in both treatment arms, though CAPS score improvements are less robust.
AB - Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are signature illnesses of the Iraq and Afghanistan wars, but current diagnostic and therapeutic measures for these conditions are suboptimal. In our study, functional magnetic resonance imaging (fMRI) is used to try to differentiate military service members with: PTSD and mTBI, PTSD alone, mTBI alone, and neither PTSD nor mTBI. Those with PTSD are then randomized to virtual reality exposure therapy or imaginal exposure. fMRI is repeated after treatment and along with the Clinician-Administered PTSD Scale (CAPS) and Clinical Global Impression (CGI) scores to compare with baseline. Twenty subjects have completed baseline fMRI scans, including four controls and one mTBI only; of 15 treated for PTSD, eight completed posttreatment scans. Most subjects have been male (93%) and Caucasian (83%), with a mean age of 34. Significant improvements are evident on fMRI scans, and corroborated by CGI scores, but CAPS scores improvements are modest. In conclusion, CGI scores and fMRI scans indicate significant improvement in PTSD in both treatment arms, though CAPS score improvements are less robust.
KW - Combat stress
KW - Exposure therapy
KW - Functional magnetic resonance imaging
KW - Posttraumatic stress disorder
KW - Traumatic brain injury
KW - Virtual reality
UR - http://www.scopus.com/inward/record.url?scp=78149263330&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2010.05689.x
DO - 10.1111/j.1749-6632.2010.05689.x
M3 - Article
C2 - 20955336
AN - SCOPUS:78149263330
SN - 0077-8923
VL - 1208
SP - 142
EP - 149
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
IS - 1
ER -