In silico modeling: Methods and applications to trauma and sepsis

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


Objectives: To familiarize clinicians with advances in computational disease modeling applied to trauma and sepsis. Data Sources: PubMed search and review of relevant medical literature. Summary: Definitions, key methods, and applications of computational modeling to trauma and sepsis are reviewed. Conclusions: Computational modeling of inflammation and organ dysfunction at the cellular, organ, whole-organism, and population levels has suggested a positive feedback cycle of inflammation → damage → inflammation that manifests via organ-specific inflammatory switching networks. This structure may manifest as multicompartment "tipping points" that drive multiple organ dysfunction. This process may be amenable to rational inflammation reprogramming.

Original languageEnglish
Pages (from-to)2008-2014
Number of pages7
JournalCritical Care Medicine
Issue number8
StatePublished - Aug 2013
Externally publishedYes


  • Inflammation
  • Mathematical model
  • Sepsis
  • Trauma


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