TY - JOUR
T1 - In vitro t cell function, delayed-type hypersensitivity skin testing, and cd4+ t cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency Virus
AU - Dolan, Matthew J.
AU - Clerici, Mario
AU - Blatt, Stephen P.
AU - Hendrix, Craig W.
AU - Melcher, Gregory P.
AU - Boswell, R. Neal
AU - Freeman, Theodore M.
AU - Ward, William
AU - Hensley, Rex
AU - Shearer, Gene M.
PY - 1995/7
Y1 - 1995/7
N2 - Human immunodeficiency virus type 1 (HIV-1)-infected patients (n = 335) in the US Air Force HIV Natural History Program were followed for 3 years (mean) after skin testing, immunophenotyping of CD4+ cell subsets, and measurement of in vitro interleukin-2 production after stimulation by phytohemagglutinin, alloantigens, tetanus toxoid, and influenza A virus. The T cell functional assay predicted survival time (P <.001) and time for progression to AIDS (P =.014). Skin testing for tetanus, mumps, and Candida antigen and the total number of positive tests (P <.001 for each) stratified patients for survival time. In a multivariable proportional hazards model, the T cell functional assay (P =.008), the absolute number of CD4+ T cells (P =.001), the percentage of CD4+CD29+ cells (P =.06), and the number of reactive skin tests (P <.001) predicted survival time. Thus, cellular immune functional tests have significant predictive value for survival time in HIV-1-infected patients independent of CD4+ cell count.
AB - Human immunodeficiency virus type 1 (HIV-1)-infected patients (n = 335) in the US Air Force HIV Natural History Program were followed for 3 years (mean) after skin testing, immunophenotyping of CD4+ cell subsets, and measurement of in vitro interleukin-2 production after stimulation by phytohemagglutinin, alloantigens, tetanus toxoid, and influenza A virus. The T cell functional assay predicted survival time (P <.001) and time for progression to AIDS (P =.014). Skin testing for tetanus, mumps, and Candida antigen and the total number of positive tests (P <.001 for each) stratified patients for survival time. In a multivariable proportional hazards model, the T cell functional assay (P =.008), the absolute number of CD4+ T cells (P =.001), the percentage of CD4+CD29+ cells (P =.06), and the number of reactive skin tests (P <.001) predicted survival time. Thus, cellular immune functional tests have significant predictive value for survival time in HIV-1-infected patients independent of CD4+ cell count.
UR - http://www.scopus.com/inward/record.url?scp=0029031796&partnerID=8YFLogxK
U2 - 10.1093/infdis/172.1.79
DO - 10.1093/infdis/172.1.79
M3 - Article
C2 - 7797948
AN - SCOPUS:0029031796
SN - 0022-1899
VL - 172
SP - 79
EP - 87
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -