In vitro t cell function, delayed-type hypersensitivity skin testing, and cd4+ t cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency Virus

Matthew J. Dolan; Mario Clerici; Stephen P. Blatt; Craig W. Hendrix; Gregory P. Melcher; R. Neal Boswell; Theodore M. Freeman; William Ward; Rex Hensley; Gene M. Shearer

doi:10.1093/infdis/172.1.79

In vitro t cell function, delayed-type hypersensitivity skin testing, and cd4⁺ t cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency Virus

Matthew J. Dolan, Mario Clerici, Stephen P. Blatt, Craig W. Hendrix, Gregory P. Melcher, R. Neal Boswell, Theodore M. Freeman, William Ward, Rex Hensley, Gene M. Shearer

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Abstract

Human immunodeficiency virus type 1 (HIV-1)-infected patients (n = 335) in the US Air Force HIV Natural History Program were followed for 3 years (mean) after skin testing, immunophenotyping of CD4⁺ cell subsets, and measurement of in vitro interleukin-2 production after stimulation by phytohemagglutinin, alloantigens, tetanus toxoid, and influenza A virus. The T cell functional assay predicted survival time (P <.001) and time for progression to AIDS (P =.014). Skin testing for tetanus, mumps, and Candida antigen and the total number of positive tests (P <.001 for each) stratified patients for survival time. In a multivariable proportional hazards model, the T cell functional assay (P =.008), the absolute number of CD4⁺ T cells (P =.001), the percentage of CD4⁺CD29⁺ cells (P =.06), and the number of reactive skin tests (P <.001) predicted survival time. Thus, cellular immune functional tests have significant predictive value for survival time in HIV-1-infected patients independent of CD4⁺ cell count.

Original language	English
Pages (from-to)	79-87
Number of pages	9
Journal	Journal of Infectious Diseases
Volume	172
Issue number	1
DOIs	https://doi.org/10.1093/infdis/172.1.79
State	Published - Jul 1995
Externally published	Yes

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Dolan, M. J., Clerici, M., Blatt, S. P., Hendrix, C. W., Melcher, G. P., Boswell, R. N., Freeman, T. M., Ward, W., Hensley, R., & Shearer, G. M. (1995). In vitro t cell function, delayed-type hypersensitivity skin testing, and cd4⁺ t cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency Virus. Journal of Infectious Diseases, 172(1), 79-87. https://doi.org/10.1093/infdis/172.1.79

@article{9a4f9a1bc7874bba94ba5ecd185f1bed,

title = "In vitro t cell function, delayed-type hypersensitivity skin testing, and cd4+ t cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency Virus",

abstract = "Human immunodeficiency virus type 1 (HIV-1)-infected patients (n = 335) in the US Air Force HIV Natural History Program were followed for 3 years (mean) after skin testing, immunophenotyping of CD4+ cell subsets, and measurement of in vitro interleukin-2 production after stimulation by phytohemagglutinin, alloantigens, tetanus toxoid, and influenza A virus. The T cell functional assay predicted survival time (P <.001) and time for progression to AIDS (P =.014). Skin testing for tetanus, mumps, and Candida antigen and the total number of positive tests (P <.001 for each) stratified patients for survival time. In a multivariable proportional hazards model, the T cell functional assay (P =.008), the absolute number of CD4+ T cells (P =.001), the percentage of CD4+CD29+ cells (P =.06), and the number of reactive skin tests (P <.001) predicted survival time. Thus, cellular immune functional tests have significant predictive value for survival time in HIV-1-infected patients independent of CD4+ cell count.",

author = "Dolan, {Matthew J.} and Mario Clerici and Blatt, {Stephen P.} and Hendrix, {Craig W.} and Melcher, {Gregory P.} and Boswell, {R. Neal} and Freeman, {Theodore M.} and William Ward and Rex Hensley and Shearer, {Gene M.}",

year = "1995",

month = jul,

doi = "10.1093/infdis/172.1.79",

language = "English",

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pages = "79--87",

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Dolan, MJ, Clerici, M, Blatt, SP, Hendrix, CW, Melcher, GP, Boswell, RN, Freeman, TM, Ward, W, Hensley, R & Shearer, GM 1995, 'In vitro t cell function, delayed-type hypersensitivity skin testing, and cd4⁺ t cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency Virus', Journal of Infectious Diseases, vol. 172, no. 1, pp. 79-87. https://doi.org/10.1093/infdis/172.1.79

In vitro t cell function, delayed-type hypersensitivity skin testing, and cd4⁺ t cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency Virus. / Dolan, Matthew J.; Clerici, Mario; Blatt, Stephen P. et al.
In: Journal of Infectious Diseases, Vol. 172, No. 1, 07.1995, p. 79-87.

Research output: Contribution to journal › Article › peer-review

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AU - Freeman, Theodore M.

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In vitro t cell function, delayed-type hypersensitivity skin testing, and cd4+ t cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency Virus

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In vitro t cell function, delayed-type hypersensitivity skin testing, and cd4⁺ t cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency Virus