In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain

Kiran Vasudeva; Yoram Vodovotz; Nabil Azhar; Derek Barclay; Jelena M. Janjic; John A. Pollock

doi:10.1016/j.jneuroim.2015.04.012

In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain

Kiran Vasudeva, Yoram Vodovotz, Nabil Azhar, Derek Barclay, Jelena M. Janjic, John A. Pollock^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Inflammation is associated with peripheral neuropathy, however the interplay among cytokines, chemokines, and neurons is still unclear. We hypothesized that this neuroinflammatory interaction can be defined by computational modeling based on the dynamics of protein expression in the sciatic nerve of rats subjected to chronic constriction injury. Using Dynamic Bayesian Network inference, we identified interleukin (IL)-18 as a central node associated with neuropathic pain in this animal model. Immunofluorescence supported a role for inflammasome activation and induction of IL-18 at the site of injury. Combined in vivo and in silico approaches may thus highlight novel targets in peripheral neuropathy.

Original language	English
Pages (from-to)	43-49
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	283
DOIs	https://doi.org/10.1016/j.jneuroim.2015.04.012
State	Published - 15 Jun 2015
Externally published	Yes

Keywords

Chronic constriction injury
Dynamic bayesian network
IL-18
Neuroinflammation
Neuropathic pain

Access to Document

10.1016/j.jneuroim.2015.04.012

Cite this

@article{e77674900ef2486b860f72fc0ec5d437,

title = "In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain",

abstract = "Inflammation is associated with peripheral neuropathy, however the interplay among cytokines, chemokines, and neurons is still unclear. We hypothesized that this neuroinflammatory interaction can be defined by computational modeling based on the dynamics of protein expression in the sciatic nerve of rats subjected to chronic constriction injury. Using Dynamic Bayesian Network inference, we identified interleukin (IL)-18 as a central node associated with neuropathic pain in this animal model. Immunofluorescence supported a role for inflammasome activation and induction of IL-18 at the site of injury. Combined in vivo and in silico approaches may thus highlight novel targets in peripheral neuropathy.",

keywords = "Chronic constriction injury, Dynamic bayesian network, IL-18, Neuroinflammation, Neuropathic pain",

author = "Kiran Vasudeva and Yoram Vodovotz and Nabil Azhar and Derek Barclay and Janjic, {Jelena M.} and Pollock, {John A.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

month = jun,

day = "15",

doi = "10.1016/j.jneuroim.2015.04.012",

language = "English",

volume = "283",

pages = "43--49",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

}

TY - JOUR

T1 - In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain

AU - Vasudeva, Kiran

AU - Vodovotz, Yoram

AU - Azhar, Nabil

AU - Barclay, Derek

AU - Janjic, Jelena M.

AU - Pollock, John A.

PY - 2015/6/15

Y1 - 2015/6/15

N2 - Inflammation is associated with peripheral neuropathy, however the interplay among cytokines, chemokines, and neurons is still unclear. We hypothesized that this neuroinflammatory interaction can be defined by computational modeling based on the dynamics of protein expression in the sciatic nerve of rats subjected to chronic constriction injury. Using Dynamic Bayesian Network inference, we identified interleukin (IL)-18 as a central node associated with neuropathic pain in this animal model. Immunofluorescence supported a role for inflammasome activation and induction of IL-18 at the site of injury. Combined in vivo and in silico approaches may thus highlight novel targets in peripheral neuropathy.

AB - Inflammation is associated with peripheral neuropathy, however the interplay among cytokines, chemokines, and neurons is still unclear. We hypothesized that this neuroinflammatory interaction can be defined by computational modeling based on the dynamics of protein expression in the sciatic nerve of rats subjected to chronic constriction injury. Using Dynamic Bayesian Network inference, we identified interleukin (IL)-18 as a central node associated with neuropathic pain in this animal model. Immunofluorescence supported a role for inflammasome activation and induction of IL-18 at the site of injury. Combined in vivo and in silico approaches may thus highlight novel targets in peripheral neuropathy.

KW - Chronic constriction injury

KW - Dynamic bayesian network

KW - IL-18

KW - Neuroinflammation

KW - Neuropathic pain

UR - http://www.scopus.com/inward/record.url?scp=84929581236&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2015.04.012

DO - 10.1016/j.jneuroim.2015.04.012

M3 - Article

C2 - 26004155

AN - SCOPUS:84929581236

SN - 0165-5728

VL - 283

SP - 43

EP - 49

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain

Abstract

Keywords

Access to Document

Fingerprint

Cite this