In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain

Kiran Vasudeva, Yoram Vodovotz, Nabil Azhar, Derek Barclay, Jelena M. Janjic, John A. Pollock*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Inflammation is associated with peripheral neuropathy, however the interplay among cytokines, chemokines, and neurons is still unclear. We hypothesized that this neuroinflammatory interaction can be defined by computational modeling based on the dynamics of protein expression in the sciatic nerve of rats subjected to chronic constriction injury. Using Dynamic Bayesian Network inference, we identified interleukin (IL)-18 as a central node associated with neuropathic pain in this animal model. Immunofluorescence supported a role for inflammasome activation and induction of IL-18 at the site of injury. Combined in vivo and in silico approaches may thus highlight novel targets in peripheral neuropathy.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalJournal of Neuroimmunology
Volume283
DOIs
StatePublished - 15 Jun 2015
Externally publishedYes

Keywords

  • Chronic constriction injury
  • Dynamic bayesian network
  • IL-18
  • Neuroinflammation
  • Neuropathic pain

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