In vivo fitness adaptations of colistin-resistant Acinetobacter baumannii isolates to oxidative stress

Crystal L. Jones*, Shweta S. Singh, Yonas Alamneh, Leila G. Casella, Robert K. Ernst, Emil P. Lesho, Paige E. Waterman, Daniel V. Zurawski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The loss of fitness in colistin-resistant (CR) Acinetobacter baumannii was investigated using longitudinal isolates from the same patient. Early CR isolates were outcompeted by late CR isolates for growth in broth and survival in the lungs of mice. Fitness loss was associated with an increased susceptibility to oxidative stress since early CR strains had reduced in vitro survival in the presence of hydrogen peroxide and decreased catalase activity compared to that of late CR and colistinsusceptible (CS) strains.

Original languageEnglish
Article numbere00598
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number3
DOIs
StatePublished - 1 Mar 2017
Externally publishedYes

Keywords

  • Acinetobacter
  • Catalase
  • ESKAPE
  • Fitness
  • Mass spectrometry
  • Mouse model
  • Serial isolation
  • Virulence

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