Increased cutaneous toxicity to ionizing radiation in HIV-positive patients

Kathleen J. Smith; Henry G. Skelton; Sylvana Tuur; Josef Yeager; Catherine Decker; Kenneth F. Wagner

doi:10.1046/j.1365-4362.1997.00255.x

Increased cutaneous toxicity to ionizing radiation in HIV-positive patients

Kathleen J. Smith, Henry G. Skelton^*, Sylvana Tuur, Josef Yeager, Catherine Decker, Kenneth F. Wagner

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Background: There are reports of increased reactions in HIV-1 + patients to ultraviolet light sometimes in association with medication. In addition, there are also reports of increased morbidity associated with radiation therapy in HIV-1+ patients. Methods: Three HIV-1+ patients developed cutaneous toxic reactions to radiation therapy; two with Kaposi's sarcoma (KS) and one with non-Hodgkin's lymphoma. Conclusions: Although the mechanisms which resulted in these reactions are not clear, they may be related to depletion of endogenous scavengers and may be accentuated by the pattern of immune dysregulation present in HIV-1 disease.

Original language	English
Pages (from-to)	779-782
Number of pages	4
Journal	International journal of dermatology
Volume	36
Issue number	10
DOIs	https://doi.org/10.1046/j.1365-4362.1997.00255.x
State	Published - Oct 1997
Externally published	Yes

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title = "Increased cutaneous toxicity to ionizing radiation in HIV-positive patients",

abstract = "Background: There are reports of increased reactions in HIV-1 + patients to ultraviolet light sometimes in association with medication. In addition, there are also reports of increased morbidity associated with radiation therapy in HIV-1+ patients. Methods: Three HIV-1+ patients developed cutaneous toxic reactions to radiation therapy; two with Kaposi's sarcoma (KS) and one with non-Hodgkin's lymphoma. Conclusions: Although the mechanisms which resulted in these reactions are not clear, they may be related to depletion of endogenous scavengers and may be accentuated by the pattern of immune dysregulation present in HIV-1 disease.",

author = "Smith, {Kathleen J.} and Skelton, {Henry G.} and Sylvana Tuur and Josef Yeager and Catherine Decker and Wagner, {Kenneth F.}",

year = "1997",

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doi = "10.1046/j.1365-4362.1997.00255.x",

language = "English",

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T1 - Increased cutaneous toxicity to ionizing radiation in HIV-positive patients

AU - Smith, Kathleen J.

AU - Skelton, Henry G.

AU - Tuur, Sylvana

AU - Yeager, Josef

AU - Decker, Catherine

AU - Wagner, Kenneth F.

PY - 1997/10

Y1 - 1997/10

N2 - Background: There are reports of increased reactions in HIV-1 + patients to ultraviolet light sometimes in association with medication. In addition, there are also reports of increased morbidity associated with radiation therapy in HIV-1+ patients. Methods: Three HIV-1+ patients developed cutaneous toxic reactions to radiation therapy; two with Kaposi's sarcoma (KS) and one with non-Hodgkin's lymphoma. Conclusions: Although the mechanisms which resulted in these reactions are not clear, they may be related to depletion of endogenous scavengers and may be accentuated by the pattern of immune dysregulation present in HIV-1 disease.

AB - Background: There are reports of increased reactions in HIV-1 + patients to ultraviolet light sometimes in association with medication. In addition, there are also reports of increased morbidity associated with radiation therapy in HIV-1+ patients. Methods: Three HIV-1+ patients developed cutaneous toxic reactions to radiation therapy; two with Kaposi's sarcoma (KS) and one with non-Hodgkin's lymphoma. Conclusions: Although the mechanisms which resulted in these reactions are not clear, they may be related to depletion of endogenous scavengers and may be accentuated by the pattern of immune dysregulation present in HIV-1 disease.

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U2 - 10.1046/j.1365-4362.1997.00255.x

DO - 10.1046/j.1365-4362.1997.00255.x

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AN - SCOPUS:0030682493

SN - 0011-9059

VL - 36

SP - 779

EP - 782

JO - International journal of dermatology

JF - International journal of dermatology

IS - 10

ER -

Increased cutaneous toxicity to ionizing radiation in HIV-positive patients

Abstract

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