Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome

Richard J. Siarey; Elaine J. Carlson; Charles J. Epstein; Andrea Balbo; Stanley I. Rapoport; Zygmunt Galdzicki

doi:10.1016/S0028-3908(99)00083-0

Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome

Richard J. Siarey
, Elaine J. Carlson
, Charles J. Epstein
, Andrea Balbo
, Stanley I. Rapoport
, Zygmunt Galdzicki^*

^*Corresponding author for this work

Anatomy, Physiology, and Genetics

Research output: Contribution to journal › Article › peer-review

174 Scopus citations

Abstract

Long-term potentiation (LTP) and depression (LTD) were investigated in hippocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse. Field excitatory postsynaptic potentials were recorded from hippocampal slices and LTP and LTD evoked sequentially. LTP decreased whereas LTD increased significantly in Ts65Dn compared with control hippocampus. Copyright (C) 1999 Elsevier Science Ltd.

Original language	English
Pages (from-to)	1917-1920
Number of pages	4
Journal	Neuropharmacology
Volume	38
Issue number	12
DOIs	https://doi.org/10.1016/S0028-3908(99)00083-0
State	Published - Dec 1999

Keywords

Down syndrome
Hippocampus
Long-term depression
Long-term potentiation
Mental retardation
Ts65Dn

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10.1016/S0028-3908(99)00083-0

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title = "Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome",

abstract = "Long-term potentiation (LTP) and depression (LTD) were investigated in hippocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse. Field excitatory postsynaptic potentials were recorded from hippocampal slices and LTP and LTD evoked sequentially. LTP decreased whereas LTD increased significantly in Ts65Dn compared with control hippocampus. Copyright (C) 1999 Elsevier Science Ltd.",

keywords = "Down syndrome, Hippocampus, Long-term depression, Long-term potentiation, Mental retardation, Ts65Dn",

author = "Siarey, \{Richard J.\} and Carlson, \{Elaine J.\} and Epstein, \{Charles J.\} and Andrea Balbo and Rapoport, \{Stanley I.\} and Zygmunt Galdzicki",

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AU - Siarey, Richard J.

AU - Carlson, Elaine J.

AU - Epstein, Charles J.

AU - Balbo, Andrea

AU - Rapoport, Stanley I.

AU - Galdzicki, Zygmunt

PY - 1999/12

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N2 - Long-term potentiation (LTP) and depression (LTD) were investigated in hippocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse. Field excitatory postsynaptic potentials were recorded from hippocampal slices and LTP and LTD evoked sequentially. LTP decreased whereas LTD increased significantly in Ts65Dn compared with control hippocampus. Copyright (C) 1999 Elsevier Science Ltd.

AB - Long-term potentiation (LTP) and depression (LTD) were investigated in hippocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse. Field excitatory postsynaptic potentials were recorded from hippocampal slices and LTP and LTD evoked sequentially. LTP decreased whereas LTD increased significantly in Ts65Dn compared with control hippocampus. Copyright (C) 1999 Elsevier Science Ltd.

KW - Down syndrome

KW - Hippocampus

KW - Long-term depression

KW - Long-term potentiation

KW - Mental retardation

KW - Ts65Dn

UR - https://www.scopus.com/pages/publications/0032729863

U2 - 10.1016/S0028-3908(99)00083-0

DO - 10.1016/S0028-3908(99)00083-0

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JO - Neuropharmacology

JF - Neuropharmacology

IS - 12

ER -

Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome

Abstract

Keywords

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