Individualized therapy for metastatic colorectal cancer

A. Silvestri; E. Pin; A. Huijbers; R. Pellicani; E. M. Parasido; M. Pierobon; E. Petricoin; L. Liotta; C. Belluco

doi:10.1111/joim.12070

Individualized therapy for metastatic colorectal cancer

A. Silvestri, E. Pin, A. Huijbers, R. Pellicani, E. M. Parasido, M. Pierobon, E. Petricoin, L. Liotta^*, C. Belluco

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Systemic therapeutic efficacy is central to determining the outcome of patients with metastatic colorectal cancer (CRC). In these patients, there is a critical need for predictive biomarkers to optimize efficacy whilst minimizing toxicity. The integration of a new generation of molecularly targeted drugs into the treatment of CRC, coupled with the development of sophisticated technologies for individual tumours as well as patient molecular profiling, underlines the potential for personalized medicine. In this review, we focus on the latest progress made within the genomic and proteomic fields, concerning predictive biomarkers for individualized therapy in metastatic CRC.

Original language	English
Pages (from-to)	1-24
Number of pages	24
Journal	Journal of Internal Medicine
Volume	274
Issue number	1
DOIs	https://doi.org/10.1111/joim.12070
State	Published - Jul 2013
Externally published	Yes

Keywords

Colorectal cancer
Genomic profiling
Individualized therapy
Predictive biomarkers
Proteomic profiling

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10.1111/joim.12070

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AU - Parasido, E. M.

AU - Pierobon, M.

AU - Petricoin, E.

AU - Liotta, L.

AU - Belluco, C.

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AB - Systemic therapeutic efficacy is central to determining the outcome of patients with metastatic colorectal cancer (CRC). In these patients, there is a critical need for predictive biomarkers to optimize efficacy whilst minimizing toxicity. The integration of a new generation of molecularly targeted drugs into the treatment of CRC, coupled with the development of sophisticated technologies for individual tumours as well as patient molecular profiling, underlines the potential for personalized medicine. In this review, we focus on the latest progress made within the genomic and proteomic fields, concerning predictive biomarkers for individualized therapy in metastatic CRC.

KW - Colorectal cancer

KW - Genomic profiling

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KW - Predictive biomarkers

KW - Proteomic profiling

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Individualized therapy for metastatic colorectal cancer

Abstract

Keywords

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