Inducible nitric oxide synthase: From cloning to therapeutic applications

Ann Schwentker; Timothy R. Billiar

doi:10.1007/s00268-002-4051-7

Inducible nitric oxide synthase: From cloning to therapeutic applications

Ann Schwentker, Timothy R. Billiar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Elucidation of the many roles of nitric oxide (NO) in homeostasis and disease states has uncovered many areas where manipulation of NO production would be of therapeutic benefit. Recent advances in gene transfer technology and the cloning of the inducible nitric oxide synthase (iNOS) gene have led to the development of strategies for gene therapy to increase NO production for the treatment of disorders ranging from vascular restenosis to impaired wound healing. This review summarizes the current status of iNOS gene therapy research.

Original language	English
Pages (from-to)	772-778
Number of pages	7
Journal	World Journal of Surgery
Volume	26
Issue number	7
DOIs	https://doi.org/10.1007/s00268-002-4051-7
State	Published - Jul 2002
Externally published	Yes

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title = "Inducible nitric oxide synthase: From cloning to therapeutic applications",

abstract = "Elucidation of the many roles of nitric oxide (NO) in homeostasis and disease states has uncovered many areas where manipulation of NO production would be of therapeutic benefit. Recent advances in gene transfer technology and the cloning of the inducible nitric oxide synthase (iNOS) gene have led to the development of strategies for gene therapy to increase NO production for the treatment of disorders ranging from vascular restenosis to impaired wound healing. This review summarizes the current status of iNOS gene therapy research.",

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AB - Elucidation of the many roles of nitric oxide (NO) in homeostasis and disease states has uncovered many areas where manipulation of NO production would be of therapeutic benefit. Recent advances in gene transfer technology and the cloning of the inducible nitric oxide synthase (iNOS) gene have led to the development of strategies for gene therapy to increase NO production for the treatment of disorders ranging from vascular restenosis to impaired wound healing. This review summarizes the current status of iNOS gene therapy research.

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Inducible nitric oxide synthase: From cloning to therapeutic applications

Abstract

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