TY - JOUR
T1 - Inductive, scaffold-based, regenerative medicine approach to reconstruction of the temporomandibular joint disk
AU - Brown, Bryan N.
AU - Chung, William L.
AU - Almarza, Alejandro J.
AU - Pavlick, Matthew D.
AU - Reppas, Serafim N.
AU - Ochs, Mark W.
AU - Russell, Alan J.
AU - Badylak, Stephen F.
N1 - Funding Information:
A portion of this study was funded by Biomet Microfixation (Jacksonville, FL) and by a grant from the National Institutes of Health (grant 5R01 AR053603 03 to S. F. Badylak).
PY - 2012/11
Y1 - 2012/11
N2 - Purpose: A device composed of extracellular matrix (ECM) was investigated as an inductive template in vivo for reconstruction of the temporomandibular joint (TMJ) disk after discectomy. Materials and Methods: A scaffold material composed of porcine-derived ECM was configured to mimic the shape and size of the TMJ. This device was implanted in a canine model of bilateral TMJ discectomy. After discectomy, 1 side was repaired with an ECM scaffold material and the contralateral side was left empty as a control. At 6 months after implantation, the joint space was opened, the joints were evaluated for signs of gross pathologic degenerative changes, and newly formed tissue was excised for histologic, biochemical, and biomechanical analysis. Results: The results showed that implantation of an initially acellular material supported the formation of site-appropriate, functional host tissue that resembled that of the native TMJ disk. Furthermore, this prevented gross degenerative changes in the temporal fossa and mandibular condyle. No tissue formation and mild to severe gross pathologic changes were observed in the contralateral controls. Conclusions: These results suggest that an ECM-based bioscaffold could represent an off-the-shelf solution for TMJ disk replacement.
AB - Purpose: A device composed of extracellular matrix (ECM) was investigated as an inductive template in vivo for reconstruction of the temporomandibular joint (TMJ) disk after discectomy. Materials and Methods: A scaffold material composed of porcine-derived ECM was configured to mimic the shape and size of the TMJ. This device was implanted in a canine model of bilateral TMJ discectomy. After discectomy, 1 side was repaired with an ECM scaffold material and the contralateral side was left empty as a control. At 6 months after implantation, the joint space was opened, the joints were evaluated for signs of gross pathologic degenerative changes, and newly formed tissue was excised for histologic, biochemical, and biomechanical analysis. Results: The results showed that implantation of an initially acellular material supported the formation of site-appropriate, functional host tissue that resembled that of the native TMJ disk. Furthermore, this prevented gross degenerative changes in the temporal fossa and mandibular condyle. No tissue formation and mild to severe gross pathologic changes were observed in the contralateral controls. Conclusions: These results suggest that an ECM-based bioscaffold could represent an off-the-shelf solution for TMJ disk replacement.
UR - http://www.scopus.com/inward/record.url?scp=84867572177&partnerID=8YFLogxK
U2 - 10.1016/j.joms.2011.12.030
DO - 10.1016/j.joms.2011.12.030
M3 - Article
C2 - 22365981
AN - SCOPUS:84867572177
SN - 0278-2391
VL - 70
SP - 2656
EP - 2668
JO - Journal of Oral and Maxillofacial Surgery
JF - Journal of Oral and Maxillofacial Surgery
IS - 11
ER -