Infectious etiologies of acute febrile illness among patients seeking health care in South-Central Cambodia

Matthew R. Kasper*, Patrick J. Blair, Sok Touch, Buth Sokhal, Chadwick Y. Yasuda, Maya Williams, Allen L. Richards, Timothy H. Burgess, Thomas F. Wierzba, Shannon D. Putnam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

The agents of human febrile illness can vary by region and country suggesting that diagnosis, treatment, and control programs need to be based on a methodical evaluation of area-specific etiologies. From December 2006 to December 2009, 9,997 individuals presenting with acute febrile illness at nine health care clinics in south-central Cambodia were enrolled in a study to elucidate the etiologies. Upon enrollment, respiratory specimens, whole blood, and serum were collected. Testing was performed for viral, bacterial, and parasitic pathogens. Etiologies were identified in 38.0% of patients. Influenza was the most frequent pathogen, followed by dengue, malaria, and bacterial pathogens isolated from blood culture. In addition, 3.5% of enrolled patients were infected with more than one pathogen. Our data provide the first systematic assessment of the etiologies of acute febrile illness in south-central Cambodia. Data from syndromic-based surveillance studies can help guide public health responses in developing nations.

Original languageEnglish
Pages (from-to)246-253
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume86
Issue number2
DOIs
StatePublished - Feb 2012

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