Infective endocarditis: 9 Questions physicians often ask

Tahaniyat Lalani*, G. Ralph Corey

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Antibiotic prophylaxis for endocarditis is strongly recommended for patients with intravascular hardware, including prosthetic valves, automatic implantable cardioverter defibrillators, pacemakers, and left ventricular assist devices. Polymerase chain reaction assays may help identify the culprit agent in culture-negative infective endocarditis (IE). Patients with Staphylococcus aureus bacteremia are at increased risk for IE and require aggressive evaluation. Several newer antistaphyloccal agents-including daptomycin, tigecycline, dalbavancin, and telavancin-show promise for the treatment of endocarditis caused by Gram-positive organisms. In patients with IE, the principal indications for valve repair or replacement are congestive heart failure from valve dysfunction; perivalvular extension, including new-onset conduction abnormalities; persistent fever for 10 or more days despite appropriate antibiotic therapy; large vegetation size; embolic phenomena; or infection with fungi, Pseudomonas aeruginosa, or S aureus.

Original languageEnglish
Pages (from-to)981-988
Number of pages8
Issue number9
StatePublished - Aug 2006


  • Antibiotic resistance
  • Bacteremia
  • Infective endocarditis
  • Staphylococcus aureus


Dive into the research topics of 'Infective endocarditis: 9 Questions physicians often ask'. Together they form a unique fingerprint.

Cite this