TY - JOUR
T1 - Influenza virus infection among pediatric patients reporting diarrhea and influenza-like illness
AU - Dilantika, Charisma
AU - Sedyaningsih, Endang R.
AU - Kasper, Matthew R.
AU - Agtini, Magdarina
AU - Listiyaningsih, Erlin
AU - Uyeki, Timothy M.
AU - Burgess, Timothy H.
AU - Blair, Patrick J.
AU - Putnam, Shannon D.
N1 - Funding Information:
The authors would like to thank all participating hospitals and clinics in the Indonesian Pediatric Diarrhea Surveillance Network. In addition, we thank all the laboratory technicians who participated in the processing of all clinical specimens; both at NAMRU2 and the National Institute of Health Research and Development, Ministry of Health. No conflicts of interest exist among any of the authors. Preliminary data for this manuscript was presented by the primary author at the 6th Annual Options for the Control of Influenza in Toronto, Canada, June 2007. Funding for this study was provided by the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center and the U.S. State Department’s Biosecurity Engagement Program. Views expressed in this article are those of the authors and do not reflect the official policy or position of the Government of Indonesia, Indonesian Ministry of Health, Indonesian National Institute of Health Research and Development, the U.S. Department of Defense, the Department of the Navy or U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia, or the US Centers for Disease Control and Prevention.
PY - 2010/1/7
Y1 - 2010/1/7
N2 - Background: Influenza is a major cause of morbidity and hospitalization among children. While less often reported in adults, gastrointestinal symptoms have been associated with influenza in children, including abdominal pain, nausea, vomiting, and diarrhea.Methods: From September 2005 and April 2008, pediatric patients in Indonesia presenting with concurrent diarrhea and influenza-like illness were enrolled in a study to determine the frequency of influenza virus infection in young patients presenting with symptoms less commonly associated with an upper respiratory tract infection (URTI). Stool specimens and upper respiratory swabs were assayed for the presence of influenza virus.Results: Seasonal influenza A or influenza B viral RNA was detected in 85 (11.6%) upper respiratory specimens and 21 (2.9%) of stool specimens. Viable influenza B virus was isolated from the stool specimen of one case. During the time of this study, human infections with highly pathogenic avian influenza A (H5N1) virus were common in the survey area. However, among 733 enrolled subjects, none had evidence of H5N1 virus infection.Conclusions: The detection of influenza viral RNA and viable influenza virus from stool suggests that influenza virus may be localized in the gastrointestinal tract of children, may be associated with pediatric diarrhea and may serve as a potential mode of transmission during seasonal and epidemic influenza outbreaks.
AB - Background: Influenza is a major cause of morbidity and hospitalization among children. While less often reported in adults, gastrointestinal symptoms have been associated with influenza in children, including abdominal pain, nausea, vomiting, and diarrhea.Methods: From September 2005 and April 2008, pediatric patients in Indonesia presenting with concurrent diarrhea and influenza-like illness were enrolled in a study to determine the frequency of influenza virus infection in young patients presenting with symptoms less commonly associated with an upper respiratory tract infection (URTI). Stool specimens and upper respiratory swabs were assayed for the presence of influenza virus.Results: Seasonal influenza A or influenza B viral RNA was detected in 85 (11.6%) upper respiratory specimens and 21 (2.9%) of stool specimens. Viable influenza B virus was isolated from the stool specimen of one case. During the time of this study, human infections with highly pathogenic avian influenza A (H5N1) virus were common in the survey area. However, among 733 enrolled subjects, none had evidence of H5N1 virus infection.Conclusions: The detection of influenza viral RNA and viable influenza virus from stool suggests that influenza virus may be localized in the gastrointestinal tract of children, may be associated with pediatric diarrhea and may serve as a potential mode of transmission during seasonal and epidemic influenza outbreaks.
UR - http://www.scopus.com/inward/record.url?scp=76849117365&partnerID=8YFLogxK
U2 - 10.1186/1471-2334-10-3
DO - 10.1186/1471-2334-10-3
M3 - Article
C2 - 20053294
AN - SCOPUS:76849117365
SN - 1471-2334
VL - 10
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
M1 - 3
ER -