Inhibition of phospholipase A2 activity by fluosol®, an artificial blood substitute

K. M.Mohames Shakir; Taffy J. Williams

doi:10.1016/0090-6980(82)90134-4

Inhibition of phospholipase A₂ activity by fluosol®, an artificial blood substitute

K. M.Mohames Shakir^*, Taffy J. Williams

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

This paper described the effect of Fluosol® on phospholipase A₂ activity both _vitro and in vivo. This compound inhibited both postheparin plasma and hepatic phospholipase A₂ activities. Furthermore, in Fluosol transfussed rats the postheparin plasma phospholipase A₂ activity was 41% below that observed in control animals. The inhibition of phospholipase A₂ activity was due to the micellar forms of pluoronic, F-68, a detergent present in Fluosol. It is postulated that the inhibition of phospholipase A₂ activity by Fluosol might interfere with the release of arachidonic acid, a substrate used in biosynthesis of prostaglandin.

Original language	English
Pages (from-to)	919-927
Number of pages	9
Journal	Prostaglandins
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/0090-6980(82)90134-4
State	Published - Jun 1982
Externally published	Yes

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10.1016/0090-6980(82)90134-4

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title = "Inhibition of phospholipase A2 activity by fluosol{\textregistered}, an artificial blood substitute",

abstract = "This paper described the effect of Fluosol{\textregistered} on phospholipase A2 activity both vitro and in vivo. This compound inhibited both postheparin plasma and hepatic phospholipase A2 activities. Furthermore, in Fluosol transfussed rats the postheparin plasma phospholipase A2 activity was 41% below that observed in control animals. The inhibition of phospholipase A2 activity was due to the micellar forms of pluoronic, F-68, a detergent present in Fluosol. It is postulated that the inhibition of phospholipase A2 activity by Fluosol might interfere with the release of arachidonic acid, a substrate used in biosynthesis of prostaglandin.",

author = "Shakir, {K. M.Mohames} and Williams, {Taffy J.}",

note = "Funding Information: We would like to express our thanks to Ms. Julie Crockett for secretarial help. This research was supported by Naval Medical Research and Development Command, Research Work Unit No. MRO412001.0399. The opinions and assertions contained herein are the private ones of the writers and are not to be construed as official or as reflecting the views of the Navy Department or the naval service at large.",

year = "1982",

month = jun,

doi = "10.1016/0090-6980(82)90134-4",

language = "English",

volume = "23",

pages = "919--927",

journal = "Prostaglandins",

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T1 - Inhibition of phospholipase A2 activity by fluosol®, an artificial blood substitute

AU - Shakir, K. M.Mohames

AU - Williams, Taffy J.

N1 - Funding Information: We would like to express our thanks to Ms. Julie Crockett for secretarial help. This research was supported by Naval Medical Research and Development Command, Research Work Unit No. MRO412001.0399. The opinions and assertions contained herein are the private ones of the writers and are not to be construed as official or as reflecting the views of the Navy Department or the naval service at large.

PY - 1982/6

Y1 - 1982/6

N2 - This paper described the effect of Fluosol® on phospholipase A2 activity both vitro and in vivo. This compound inhibited both postheparin plasma and hepatic phospholipase A2 activities. Furthermore, in Fluosol transfussed rats the postheparin plasma phospholipase A2 activity was 41% below that observed in control animals. The inhibition of phospholipase A2 activity was due to the micellar forms of pluoronic, F-68, a detergent present in Fluosol. It is postulated that the inhibition of phospholipase A2 activity by Fluosol might interfere with the release of arachidonic acid, a substrate used in biosynthesis of prostaglandin.

AB - This paper described the effect of Fluosol® on phospholipase A2 activity both vitro and in vivo. This compound inhibited both postheparin plasma and hepatic phospholipase A2 activities. Furthermore, in Fluosol transfussed rats the postheparin plasma phospholipase A2 activity was 41% below that observed in control animals. The inhibition of phospholipase A2 activity was due to the micellar forms of pluoronic, F-68, a detergent present in Fluosol. It is postulated that the inhibition of phospholipase A2 activity by Fluosol might interfere with the release of arachidonic acid, a substrate used in biosynthesis of prostaglandin.

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U2 - 10.1016/0090-6980(82)90134-4

DO - 10.1016/0090-6980(82)90134-4

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JO - Prostaglandins

JF - Prostaglandins

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ER -

Inhibition of phospholipase A2 activity by fluosol®, an artificial blood substitute

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Inhibition of phospholipase A₂ activity by fluosol®, an artificial blood substitute