Inhibition of synexin activity and exocytosis from chromaffin cells by phenothiazine drugs

Harvey B. Pollard; Janet H. Scott; Carl E. Creutz

doi:10.1016/0006-291X(83)91085-9

Inhibition of synexin activity and exocytosis from chromaffin cells by phenothiazine drugs

Harvey B. Pollard^*
, Janet H. Scott
, Carl E. Creutz

^*Corresponding author for this work

Anatomy, Physiology, and Genetics

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Synexin activity was found to be inhibited by low concentrations of the phenothiazine drugs, trifluoperazine and promethazine. Both drugs were also similarly effective at blocking nicotine and veratridine-induced catecholamine secretion from cultured chromaffin cells. These data thus indicate that synexin may be a target of phenothiazine drugs when they block secretion from chromaffin cells.

Original language	English
Pages (from-to)	908-915
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	113
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(83)91085-9
State	Published - 29 Jun 1983

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title = "Inhibition of synexin activity and exocytosis from chromaffin cells by phenothiazine drugs",

abstract = "Synexin activity was found to be inhibited by low concentrations of the phenothiazine drugs, trifluoperazine and promethazine. Both drugs were also similarly effective at blocking nicotine and veratridine-induced catecholamine secretion from cultured chromaffin cells. These data thus indicate that synexin may be a target of phenothiazine drugs when they block secretion from chromaffin cells.",

author = "Pollard, \{Harvey B.\} and Scott, \{Janet H.\} and Creutz, \{Carl E.\}",

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AU - Pollard, Harvey B.

AU - Scott, Janet H.

AU - Creutz, Carl E.

PY - 1983/6/29

Y1 - 1983/6/29

N2 - Synexin activity was found to be inhibited by low concentrations of the phenothiazine drugs, trifluoperazine and promethazine. Both drugs were also similarly effective at blocking nicotine and veratridine-induced catecholamine secretion from cultured chromaffin cells. These data thus indicate that synexin may be a target of phenothiazine drugs when they block secretion from chromaffin cells.

AB - Synexin activity was found to be inhibited by low concentrations of the phenothiazine drugs, trifluoperazine and promethazine. Both drugs were also similarly effective at blocking nicotine and veratridine-induced catecholamine secretion from cultured chromaffin cells. These data thus indicate that synexin may be a target of phenothiazine drugs when they block secretion from chromaffin cells.

UR - https://www.scopus.com/pages/publications/0020639052

U2 - 10.1016/0006-291X(83)91085-9

DO - 10.1016/0006-291X(83)91085-9

M3 - Article

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AN - SCOPUS:0020639052

SN - 0006-291X

VL - 113

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EP - 915

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Inhibition of synexin activity and exocytosis from chromaffin cells by phenothiazine drugs

Abstract

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