Initial evaluation of a nano-engineered hemostatic agent in a severe vascular and organ hemorrhage swine model

Françoise Arnaud*, Tomoaki Okada, Daniel Solomon, Ashraful Haque, Erica E. Carroll, Eilleen Sagini, Richard McCarron

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

OBJECTIVES: An advanced hemostatic dressing, Rapid Trauma Hemostat (RTH), was developed using nano-engineered inorganic nanofibers with hemostatic surface properties. METHODS: Yorkshire swine were treated with RTH or Combat Gauze (CBG) to stop bleeding from either an arterial puncture (G-RTH and G-CBG) or a liver lobe laceration (L-RTH and L-CBG). All animals received 500 mL of Hextend at 10 minutes after injury and were monitored for a total time of 180 minutes. RESULTS: Uncontrolled hemorrhage was similar in all animals in both models and was immediately controlled with the application of either dressing. After blood pressure was restored with fluid resuscitation, the RTH hemostatic treatment was less effective than CBG in the groin (puncture) model (rebleeding incidence, four of seven for G-RTH vs. one of seven for G-CBG; p = 0.034) but showed similar efficacy in the liver injury model (lower pressure bleeding). Interestingly, RTH exhibited a trend for higher efficacy in terms of hemostatic plug formation at the end of the experiment (no bleeding occurred after dressing removal) in the liver injury model. CONCLUSION: Overall, RTH was not as effective at stopping high-shear rate (arterial) bleeding, but it presented some advantages for intracavitary treatment with potential for long-term evacuation.

Original languageEnglish
Pages (from-to)1180-1187
Number of pages8
JournalJournal of Trauma and Acute Care Surgery
Volume73
Issue number5
DOIs
StatePublished - Nov 2012
Externally publishedYes

Keywords

  • Bleeding
  • Hemostatic dressing
  • Liver repair
  • Nanofibers
  • Trauma

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