Innate immune response to Anaplasma phagocytophilum contributes to hepatic injury

Diana G. Scorpio; Friederike D. Von Loewenich; Heike Göbel; Christian Bogdan; J. Stephen Dumler

doi:10.1128/CVI.00092-06

Innate immune response to Anaplasma phagocytophilum contributes to hepatic injury

Diana G. Scorpio^*
, Friederike D. Von Loewenich
, Heike Göbel
, Christian Bogdan
, J. Stephen Dumler

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

In mice, Anaplasma phagocytophilum control is independent of phagocyte oxidase (phox), inducible NO synthase (NOS2), tumor necrosis factor (TNF), and MyD88 Toll-like receptor signaling. We show that despite evasion of these host responses, phox, NOS2, TNF, and MyD88 are activated and contribute to inflammation and hepatic injury more than A. phagocytophilum itself.

Original language	English
Pages (from-to)	806-809
Number of pages	4
Journal	Clinical and Vaccine Immunology
Volume	13
Issue number	7
DOIs	https://doi.org/10.1128/CVI.00092-06
State	Published - Jul 2006

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abstract = "In mice, Anaplasma phagocytophilum control is independent of phagocyte oxidase (phox), inducible NO synthase (NOS2), tumor necrosis factor (TNF), and MyD88 Toll-like receptor signaling. We show that despite evasion of these host responses, phox, NOS2, TNF, and MyD88 are activated and contribute to inflammation and hepatic injury more than A. phagocytophilum itself.",

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AU - Göbel, Heike

AU - Bogdan, Christian

AU - Dumler, J. Stephen

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AB - In mice, Anaplasma phagocytophilum control is independent of phagocyte oxidase (phox), inducible NO synthase (NOS2), tumor necrosis factor (TNF), and MyD88 Toll-like receptor signaling. We show that despite evasion of these host responses, phox, NOS2, TNF, and MyD88 are activated and contribute to inflammation and hepatic injury more than A. phagocytophilum itself.

UR - https://www.scopus.com/pages/publications/33748035708

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JO - Clinical and Vaccine Immunology

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Innate immune response to Anaplasma phagocytophilum contributes to hepatic injury

Abstract

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