Integrated genomic characterization of endometrial carcinoma

Gad Getz, Stacey B. Gabriel, Kristian Cibulskis, Eric Lander, Andrey Sivachenko, Carrie Sougnez, Mike Lawrence, Cyriac Kandoth, David Dooling, Robert Fulton, Lucinda Fulton, Joelle Kalicki-Veizer, Michael D. McLellan, Michelle O'Laughlin, Heather Schmidt, Richard K. Wilson, Kai Ye, Ding Li, Adrian Ally, Miruna BalasundaramInanc Birol, Yaron S.N. Butterfield, Rebecca Carlsen, Candace Carter, Andy Chu, Eric Chuah, Hye Jung E. Chun, Noreen Dhalla, Ranabir Guin, Carrie Hirst, Robert A. Holt, Steven J.M. Jones, Darlene Lee, Haiyan I. Li, Marco A. Marra, Michael Mayo, Richard A. Moore, Andrew J. Mungall, Patrick Plettner, Jacqueline E. Schein, Payal Sipahimalani, Angela Tam, Richard J. Varhol, A. Gordon Robertson, Andrew D. Cherniack, Itai Pashtan, Gordon Saksena, Robert C. Onofrio, Steven E. Schumacher, Barbara Tabak, Scott L. Carter, Bryan Hernandez, Jeff Gentry, Helga B. Salvesen, Kristin Ardlie, Wendy Winckler, Rameen Beroukhim, Matthew Meyerson, Angela Hadjipanayis, Semin Lee, Harshad S. Mahadeshwar, Peter Park, Alexei Protopopov, Xiaojia Ren, Sahil Seth, Xingzhi Song, Jiabin Tang, Ruibin Xi, Lixing Yang, Zeng Dong, Raju Kucherlapati, Lynda Chin, Jianhua Zhang, J. Todd Auman, Saianand Balu, Tom Bodenheimer, Elizabeth Buda, D. Neil Hayes, Alan P. Hoyle, Stuart R. Jefferys, Corbin D. Jones, Shaowu Meng, Piotr A. Mieczkowski, Lisle E. Mose, Joel S. Parker, Charles M. Perou, Jeff Roach, Shi Yan, Janae V. Simons, Mathew G. Soloway, Donghui Tan, Michael D. Topal, Scot Waring, Junyuan Wu, Katherine A. Hoadley, Stephen B. Baylin, Moiz S. Bootwalla, Phillip H. Lai, Timothy J. Triche, David J. Van Den Berg, Daniel J. Weisenberger, Peter W. Laird, Hui Shen, Juok Cho, Daniel Dicara, Scott Frazer, David Heiman, Rui Jing, Pei Lin, Will Mallard, Petar Stojanov, Doug Voet, Hailei Zhang, Lihua Zou, Michael Noble, Sheila M. Reynolds, Ilya Shmulevich, B. Arman Aksoy, Yevgeniy Antipin, Giovanni Ciriello, Gideon Dresdner, Jianjiong Gao, Benjamin Gross, Anders Jacobsen, Marc Ladanyi, Boris Reva, Chris Sander, Rileen Sinha, S. Onur Sumer, Barry S. Taylor, Ethan Cerami, Nils Weinhold, Nikolaus Schultz, Ronglai Shen, Stephen Benz, Ted Goldstein, David Haussler, Sam Ng, Christopher Szeto, Joshua Stuart, Christopher C. Benz, Christina Yau, Wei Zhang, Matti Annala, Bradley M. Broom, Tod D. Casasent, Zhenlin Ju, Han Liang, Guoyan Liu, Yiling Lu, Anna K. Unruh, Chris Wakefield, John N. Weinstein, Nianxiang Zhang, Yuexin Liu, Russell Broaddus, Rehan Akbani, Gordon B. Mills, Christopher Adams, Thomas Barr, Aaron D. Black, Jay Bowen, John Deardurff, Jessica Frick, Julie M. Gastier-Foster, Thomas Grossman, Hollie A. Harper, Melissa Hart-Kothari, Carmen Helsel, Aaron Hobensack, Harkness Kuck, Kelley Kneile, Kristen M. Leraas, Tara M. Lichtenberg, Cynthia McAllister, Robert E. Pyatt, Nilsa C. Ramirez, Teresa R. Tabler, Nathan Vanhoose, Peter White, Lisa Wise, Erik Zmuda, Nandita Barnabas, Charlenia Berry-Green, Victoria Blanc, Lori Boice, Michael Button, Adam Farkas, Alex Green, Jean MacKenzie, Dana Nicholson, Steve E. Kalloger, C. Blake Gilks, Beth Y. Karlan, Jenny Lester, Sandra Orsulic, Mark Borowsky, Mark Cadungog, Christine Czerwinski, Lori Huelsenbeck-Dill, Mary Iacocca, Nicholas Petrelli, Brenda Rabeno, Gary Witkin, Elena Nemirovich-Danchenko, Olga Potapova, Daniil Rotin, Andrew Berchuck, Michael Birrer, Phillip Disaia, Laura Monovich, Erin Curley, Johanna Gardner, David Mallery, Robert Penny, Sean C. Dowdy, Boris Winterhoff, Linda Dao, Bobbie Gostout, Alexandra Meuter, Attila Teoman, Fanny Dao, Narciso Olvera, Faina Bogomolniy, Karuna Garg, Robert A. Soslow, Mikhail Abramov, John M.S. Bartlett, Sugy Kodeeswaran, Jeremy Parfitt, Fedor Moiseenko, Blaise A. Clarke, Marc T. Goodman, Michael E. Carney, Rayna K. Matsuno, Jennifer Fisher, Mei Huang, W. Kimryn Rathmell, Leigh Thorne, Linda Van Le, Rajiv Dhir, Robert Edwards, Esther Elishaev, Kristin Zorn, Paul J. Goodfellow, David Mutch, Ari B. Kahn, Daphne W. Bell, Pamela M. Pollock, Chen Wang, David Wheeler, Eve Shinbrot, A. Gordon Robertson, Li Ding, C. Blake Gilks, Elaine R. Mardis, Brenda Ayala, Anna L. Chu, Mark A. Jensen, Prachi Kothiyal, Todd D. Pihl, Joan Pontius, David A. Pot, Eric E. Snyder, Deepak Srinivasan, Kenna R. Mills Shaw, Margi Sheth, Tanja Davidsen, Greg Eley, Martin L. Ferguson, Liming Yang, Mark S. Guyer, Bradley A. Ozenberger, Heidi J. Sofia, A. Gordon Robertson, Douglas A. Levine*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3929 Scopus citations

Abstract

We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array-and sequencing-based technologies. Uterine serous tumours and ∼25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalNature
Volume497
Issue number7447
DOIs
StatePublished - 2013
Externally publishedYes

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