Integration of Protein Network Activation Mapping Technology for Personalized Therapy. Implications for Pancreatic Cancer.

Mariaelena Pierobon*, Julie Wulfkuhle, Lance A. Liotta, Emanuel F. Petricoin

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Genomic analysis of pancreatic cancer and other solid tumors has revealed that cancer is a proteomic network disease at the functional level. Protein pathway activation is measured by posttranslational modifications such as phosphorylation that control cellular signaling, and these events are not effectively measured by DNA or RNA analysis alone. In fact, these signaling pathways represent the targets for the molecularly targeted therapeutics, and so it is critical that we begin to define human cancer at a functional pathway activation level. Reverse phase protein microarrays is a key enabling new technology that can generate a functional map of activated protein networks directly from a biopsy specimen. This patient-specific "circuit diagram" provides key information for individualized therapy and can be integrated into a multi-omic systems-level portrait of genomic-to-proteomic information content. The identification of activated protein drug target networks in pancreatic tumors can then be used for drug selection and patient stratification wherein the activated protein "circuit diagram" becomes the ultimate companion diagnostic assay for systems medicine.

Original languageEnglish
Title of host publicationMolecular Diagnostics and Treatment of Pancreatic Cancer
PublisherElsevier Inc.
Pages367-383
Number of pages17
ISBN (Print)9780124081031
DOIs
StatePublished - Apr 2014
Externally publishedYes

Keywords

  • Biomarkers
  • Cell signaling
  • Companion diagnostics
  • Oncology
  • Pancreatic cancer
  • Pathway mapping
  • Personalized therapy
  • Phosphoprotein

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