Integrative Network Analysis Linking Clinical Outcomes with Environmental Exposures and Molecular Variations in Service Personnel Deployed to Balad and Bagram

Juilee Thakar; Thomas H. Thatcher; Matthew Ryan Smith; Collynn F. Woeller; Douglas I. Walker; Mark J. Utell; Philip K. Hopke; Timothy M. Mallon; Pamela L. Krahl; Patricia Rohrbeck; Young Mi Go; Dean P. Jones; Karan Uppal

doi:10.1097/JOM.0000000000001710

Integrative Network Analysis Linking Clinical Outcomes with Environmental Exposures and Molecular Variations in Service Personnel Deployed to Balad and Bagram

Juilee Thakar, Thomas H. Thatcher, Matthew Ryan Smith, Collynn F. Woeller, Douglas I. Walker, Mark J. Utell, Philip K. Hopke, Timothy M. Mallon, Pamela L. Krahl, Patricia Rohrbeck, Young Mi Go, Dean P. Jones, Karan Uppal^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective:To develop a computational approach to link clinical outcomes with environmental exposures and molecular variations measured in Department of Defense (DOD) serum-repository samples.Methods:International Classification of Diseases, Ninth Division codes which corresponded to cardiopulmonary symptoms for service personnel were selected to test for associations with deployment-related inhalation hazards and metabolomics, micro-RNA, cytokine, plasma markers, and environmental exposure analyses for corresponding samples. xMWAS and Mummichog were used for integrative network and pathway analysis.Results:Comparison between 41 personnel exhibiting new cardio-pulmonary diagnoses after deployment start-date to 25 personnel exhibiting no symptoms identified biomarkers associated with cardiopulmonary conditions. Integrative network and pathway analysis showed communities of clinical, molecular, and environmental markers associated with fatty acid, lipid, nucleotide, and amino acid metabolism pathways.Conclusions:The current proof of principle study establishes a computational framework for integrative analysis of deployment-related exposures, molecular responses, and health outcomes.

Original language	English
Pages (from-to)	S65-S72
Journal	Journal of Occupational and Environmental Medicine
Volume	61
DOIs	https://doi.org/10.1097/JOM.0000000000001710
State	Published - 1 Dec 2019
Externally published	Yes

Keywords

Department of Defense serum repository
exposome
hazardous exposures
health surveillance
systems biology

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10.1097/JOM.0000000000001710

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Thakar, J., Thatcher, T. H., Smith, M. R., Woeller, C. F., Walker, D. I., Utell, M. J., Hopke, P. K., Mallon, T. M., Krahl, P. L., Rohrbeck, P., Go, Y. M., Jones, D. P., & Uppal, K. (2019). Integrative Network Analysis Linking Clinical Outcomes with Environmental Exposures and Molecular Variations in Service Personnel Deployed to Balad and Bagram. Journal of Occupational and Environmental Medicine, 61, S65-S72. https://doi.org/10.1097/JOM.0000000000001710

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title = "Integrative Network Analysis Linking Clinical Outcomes with Environmental Exposures and Molecular Variations in Service Personnel Deployed to Balad and Bagram",

abstract = "Objective:To develop a computational approach to link clinical outcomes with environmental exposures and molecular variations measured in Department of Defense (DOD) serum-repository samples.Methods:International Classification of Diseases, Ninth Division codes which corresponded to cardiopulmonary symptoms for service personnel were selected to test for associations with deployment-related inhalation hazards and metabolomics, micro-RNA, cytokine, plasma markers, and environmental exposure analyses for corresponding samples. xMWAS and Mummichog were used for integrative network and pathway analysis.Results:Comparison between 41 personnel exhibiting new cardio-pulmonary diagnoses after deployment start-date to 25 personnel exhibiting no symptoms identified biomarkers associated with cardiopulmonary conditions. Integrative network and pathway analysis showed communities of clinical, molecular, and environmental markers associated with fatty acid, lipid, nucleotide, and amino acid metabolism pathways.Conclusions:The current proof of principle study establishes a computational framework for integrative analysis of deployment-related exposures, molecular responses, and health outcomes.",

keywords = "Department of Defense serum repository, exposome, hazardous exposures, health surveillance, systems biology",

author = "Juilee Thakar and Thatcher, {Thomas H.} and Smith, {Matthew Ryan} and Woeller, {Collynn F.} and Walker, {Douglas I.} and Utell, {Mark J.} and Hopke, {Philip K.} and Mallon, {Timothy M.} and Krahl, {Pamela L.} and Patricia Rohrbeck and Go, {Young Mi} and Jones, {Dean P.} and Karan Uppal",

note = "Publisher Copyright: {\textcopyright} 2019 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited.",

year = "2019",

month = dec,

day = "1",

doi = "10.1097/JOM.0000000000001710",

language = "English",

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Thakar, J, Thatcher, TH, Smith, MR, Woeller, CF, Walker, DI, Utell, MJ, Hopke, PK, Mallon, TM, Krahl, PL, Rohrbeck, P, Go, YM, Jones, DP & Uppal, K 2019, 'Integrative Network Analysis Linking Clinical Outcomes with Environmental Exposures and Molecular Variations in Service Personnel Deployed to Balad and Bagram', Journal of Occupational and Environmental Medicine, vol. 61, pp. S65-S72. https://doi.org/10.1097/JOM.0000000000001710

Integrative Network Analysis Linking Clinical Outcomes with Environmental Exposures and Molecular Variations in Service Personnel Deployed to Balad and Bagram. / Thakar, Juilee; Thatcher, Thomas H.; Smith, Matthew Ryan et al.
In: Journal of Occupational and Environmental Medicine, Vol. 61, 01.12.2019, p. S65-S72.

Research output: Contribution to journal › Article › peer-review

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T1 - Integrative Network Analysis Linking Clinical Outcomes with Environmental Exposures and Molecular Variations in Service Personnel Deployed to Balad and Bagram

AU - Thakar, Juilee

AU - Thatcher, Thomas H.

AU - Smith, Matthew Ryan

AU - Woeller, Collynn F.

AU - Walker, Douglas I.

AU - Utell, Mark J.

AU - Hopke, Philip K.

AU - Mallon, Timothy M.

AU - Krahl, Pamela L.

AU - Rohrbeck, Patricia

AU - Go, Young Mi

AU - Jones, Dean P.

AU - Uppal, Karan

PY - 2019/12/1

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N2 - Objective:To develop a computational approach to link clinical outcomes with environmental exposures and molecular variations measured in Department of Defense (DOD) serum-repository samples.Methods:International Classification of Diseases, Ninth Division codes which corresponded to cardiopulmonary symptoms for service personnel were selected to test for associations with deployment-related inhalation hazards and metabolomics, micro-RNA, cytokine, plasma markers, and environmental exposure analyses for corresponding samples. xMWAS and Mummichog were used for integrative network and pathway analysis.Results:Comparison between 41 personnel exhibiting new cardio-pulmonary diagnoses after deployment start-date to 25 personnel exhibiting no symptoms identified biomarkers associated with cardiopulmonary conditions. Integrative network and pathway analysis showed communities of clinical, molecular, and environmental markers associated with fatty acid, lipid, nucleotide, and amino acid metabolism pathways.Conclusions:The current proof of principle study establishes a computational framework for integrative analysis of deployment-related exposures, molecular responses, and health outcomes.

AB - Objective:To develop a computational approach to link clinical outcomes with environmental exposures and molecular variations measured in Department of Defense (DOD) serum-repository samples.Methods:International Classification of Diseases, Ninth Division codes which corresponded to cardiopulmonary symptoms for service personnel were selected to test for associations with deployment-related inhalation hazards and metabolomics, micro-RNA, cytokine, plasma markers, and environmental exposure analyses for corresponding samples. xMWAS and Mummichog were used for integrative network and pathway analysis.Results:Comparison between 41 personnel exhibiting new cardio-pulmonary diagnoses after deployment start-date to 25 personnel exhibiting no symptoms identified biomarkers associated with cardiopulmonary conditions. Integrative network and pathway analysis showed communities of clinical, molecular, and environmental markers associated with fatty acid, lipid, nucleotide, and amino acid metabolism pathways.Conclusions:The current proof of principle study establishes a computational framework for integrative analysis of deployment-related exposures, molecular responses, and health outcomes.

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ER -

Integrative Network Analysis Linking Clinical Outcomes with Environmental Exposures and Molecular Variations in Service Personnel Deployed to Balad and Bagram

Abstract

Keywords

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