@article{ebb4184affd242c28eba1def79521ec4,
title = "International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations",
abstract = "Recombinant adenovirus serotype 5 (rAd5) vaccine vectors for HIV-1 and other pathogens have been shown to be limited by high titers of Ad5 neutralizing antibodies (NAbs) in the developing world. Alternative serotype rAd vectors have therefore been constructed. Here we report Ad5, Ad26, Ad35, and Ad48 NAb titers in 4381 individuals from North America, South America, sub-Saharan Africa, and Southeast Asia. As expected, Ad5 NAb titers were both frequent and high magnitude in sub-Saharan Africa and Southeast Asia. In contrast, Ad35 NAb titers proved infrequent and low in all regions studied, and Ad48 NAbs were rare in all regions except East Africa. Ad26 NAbs were moderately common in adults in sub-Saharan Africa and Southeast Asia, but Ad26 NAb titers proved markedly lower than Ad5 NAb titers in all regions, and these relatively low Ad26 NAb titers did not detectably suppress the immunogenicity of 4×10 10vp of a rAd26-Gag/Pol/Env/Nef vaccine in rhesus monkeys. These data inform the clinical development of alternative serotype rAd vaccine vectors in the developing world.",
keywords = "Adenovirus, HIV-1, Vaccine, Vector",
author = "Barouch, {Dan H.} and Kik, {Sandra V.} and Weverling, {Gerrit J.} and Rebecca Dilan and King, {Sharon L.} and Maxfield, {Lori F.} and Sarah Clark and David Ng'ang'a and Brandariz, {Kara L.} and Peter Abbink and Faruk Sinangil and {de Bruyn}, Guy and Gray, {Glenda E.} and Surita Roux and Bekker, {Linda Gail} and Athmanundh Dilraj and Hannah Kibuuka and Robb, {Merlin L.} and Michael, {Nelson L.} and Omu Anzala and Amornkul, {Pauli N.} and Jill Gilmour and John Hural and Buchbinder, {Susan P.} and Seaman, {Michael S.} and Raphael Dolin and Baden, {Lindsey R.} and Angela Carville and Mansfield, {Keith G.} and Pau, {Maria G.} and Jaap Goudsmit",
note = "Funding Information: We thank A. Riggs, D. Lynch, A. La Porte, N. Simmons, J. Iampietro, F. Stephens, D. Casimiro, M. Robertson, J. Shiver, J. McElrath, B. Farrah, J. Cox, P. Fast, H. Jaspan, G. Stevens, P. Chetty, T. Tarragona, L. Clark, A. Raxworthy-Cooper, M. Price, E. Cormier, K. Higgins, and M. Pensiero for generous advice, assistance, and reagents. We acknowledge support from the U.S. National Institutes of Health ( AI066305 , AI066924 , AI078526 ), the Bill & Melinda Gates Foundation ( #38614 ), the Elizabeth Glaser Pediatric AIDS Foundation , and the Ragon Institute of MGH , MIT , and Harvard . The IAVI samples were collected with funding from the U.S. Agency for International Development ( GPO-A-00-06-00006-00 ). The MIRA and PIP samples were collected with funding from the Bill & Melinda Gates Foundation . ",
year = "2011",
month = jul,
day = "18",
doi = "10.1016/j.vaccine.2011.05.025",
language = "English",
volume = "29",
pages = "5203--5209",
journal = "Vaccine",
issn = "0264-410X",
number = "32",
}