Interrelationship between calcium and aluminum metabolism in dialyzed uremic patients

Bones from dialysis patients with aluminum concentrations greater than 100 mg/kg had significantly less ash content than bones containing less than 100 mg/kg aluminum. Neither parathyroid hormone nor 1,25(OH)₂D₃ were found to interfere with aluminum metabolism showing that bone aluminum was not affected by these hormonal alterations present in the uremic state. Bone aluminum correlated directly and ash inversely with duration of dialysis suggesting that the increased bone aluminum could be either a result of longer duration on dialysis or else it could in part be responsible for the progressive bone disease which may occur in dialyzed uremic patients.