Intestine submucosa and polypropylene mesh for abdominal wall repair in dogs

Kevin M. Clarke, Gary C. Lantz*, S. Kathleen Salisbury, Stephen F. Badylak, Michael C. Hiles, Sherry L. Voytik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

240 Scopus citations


Continuing investigations of abdominal body wall reconstruction materials suggest that unacceptable implant complications continue and that the ideal material has not yet been found. This pilot study compared xenogeneic (porcine) small intestine submucosa (SIS) with polypropylene mesh (PPM) for repair of created partial-thickness (six dogs) and full-thickness (six dogs) abdominal wall defects. Postoperative clinical evaluation of all dogs showed no evidence of implant failure. Dogs were euthanized at 1, 2, and 4 months after surgery. The SIS implants were completely replaced by host tissue at 4 months as determined by immunohistochemistry. The resultant repair was well- organized, smooth, dense collagenous connective tissue that was well incorporated into the adjacent fascia and skeletal muscle fiber bundles. In the full-thickness defect dogs, omentum covered a significantly larger portion of PPM (P = 0.001) and was more firmly attached to PPM (P = 0.0001) compared to SIS/connective tissue repair. We conclude that xenogeneic SIS can be used as an abdominal body wall repair material in the dog and warrants further investigations.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalJournal of Surgical Research
Issue number1
StatePublished - Jan 1996
Externally publishedYes


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