Intravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation

R Nee, D Doppenschmidt, D J Donovan, T C Andrews

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


Our data suggest that compared with the subcutaneous route of administration, intravenous vitamin K1 results in a more prompt reduction in the international normalized ration. However, for most patients, subcutaneous vitamin K1 is an effective and safe alternative when used in conjunction with modification of subsequent warfarin dosing, because virtually all patients achieved a safe level of anticoagulation within 72 hours with this route of administration.

Original languageEnglish
Pages (from-to)286-8, A6-7
JournalThe American Journal of Cardiology
Issue number2
StatePublished - 15 Jan 1999
Externally publishedYes


  • Adult
  • Analysis of Variance
  • Anticoagulants/antagonists & inhibitors
  • Antifibrinolytic Agents/administration & dosage
  • Blood Coagulation/drug effects
  • Dose-Response Relationship, Drug
  • Humans
  • Injections, Intravenous
  • Injections, Subcutaneous
  • International Normalized Ratio
  • Vitamin K 1/administration & dosage
  • Warfarin/antagonists & inhibitors


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