Intravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation

R Nee; D Doppenschmidt; D J Donovan; T C Andrews

doi:10.1016/s0002-9149(98)00842-x

Intravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation

R Nee, D Doppenschmidt, D J Donovan, T C Andrews

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Our data suggest that compared with the subcutaneous route of administration, intravenous vitamin K1 results in a more prompt reduction in the international normalized ration. However, for most patients, subcutaneous vitamin K1 is an effective and safe alternative when used in conjunction with modification of subsequent warfarin dosing, because virtually all patients achieved a safe level of anticoagulation within 72 hours with this route of administration.

Original language	English
Pages (from-to)	286-8, A6-7
Journal	The American Journal of Cardiology
Volume	83
Issue number	2
DOIs	https://doi.org/10.1016/s0002-9149(98)00842-x
State	Published - 15 Jan 1999
Externally published	Yes

Keywords

Adult
Analysis of Variance
Anticoagulants/antagonists & inhibitors
Antifibrinolytic Agents/administration & dosage
Blood Coagulation/drug effects
Dose-Response Relationship, Drug
Humans
Injections, Intravenous
Injections, Subcutaneous
International Normalized Ratio
Vitamin K 1/administration & dosage
Warfarin/antagonists & inhibitors

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10.1016/s0002-9149(98)00842-x

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title = "Intravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation",

abstract = "Our data suggest that compared with the subcutaneous route of administration, intravenous vitamin K1 results in a more prompt reduction in the international normalized ration. However, for most patients, subcutaneous vitamin K1 is an effective and safe alternative when used in conjunction with modification of subsequent warfarin dosing, because virtually all patients achieved a safe level of anticoagulation within 72 hours with this route of administration.",

keywords = "Adult, Analysis of Variance, Anticoagulants/antagonists & inhibitors, Antifibrinolytic Agents/administration & dosage, Blood Coagulation/drug effects, Dose-Response Relationship, Drug, Humans, Injections, Intravenous, Injections, Subcutaneous, International Normalized Ratio, Vitamin K 1/administration & dosage, Warfarin/antagonists & inhibitors",

author = "R Nee and D Doppenschmidt and Donovan, {D J} and Andrews, {T C}",

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doi = "10.1016/s0002-9149(98)00842-x",

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AU - Nee, R

AU - Doppenschmidt, D

AU - Donovan, D J

AU - Andrews, T C

PY - 1999/1/15

Y1 - 1999/1/15

N2 - Our data suggest that compared with the subcutaneous route of administration, intravenous vitamin K1 results in a more prompt reduction in the international normalized ration. However, for most patients, subcutaneous vitamin K1 is an effective and safe alternative when used in conjunction with modification of subsequent warfarin dosing, because virtually all patients achieved a safe level of anticoagulation within 72 hours with this route of administration.

AB - Our data suggest that compared with the subcutaneous route of administration, intravenous vitamin K1 results in a more prompt reduction in the international normalized ration. However, for most patients, subcutaneous vitamin K1 is an effective and safe alternative when used in conjunction with modification of subsequent warfarin dosing, because virtually all patients achieved a safe level of anticoagulation within 72 hours with this route of administration.

KW - Adult

KW - Analysis of Variance

KW - Anticoagulants/antagonists & inhibitors

KW - Antifibrinolytic Agents/administration & dosage

KW - Blood Coagulation/drug effects

KW - Dose-Response Relationship, Drug

KW - Humans

KW - Injections, Intravenous

KW - Injections, Subcutaneous

KW - International Normalized Ratio

KW - Vitamin K 1/administration & dosage

KW - Warfarin/antagonists & inhibitors

U2 - 10.1016/s0002-9149(98)00842-x

DO - 10.1016/s0002-9149(98)00842-x

M3 - Article

C2 - 10073841

SN - 0002-9149

VL - 83

SP - 286-8, A6-7

JO - The American Journal of Cardiology

JF - The American Journal of Cardiology

IS - 2

ER -

Intravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation

Abstract

Keywords

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