Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay

Kate L. Seib, Mark P. Simons, Hsing Ju Wu, Alastair G. McEwan, William M. Nauseef, Michael A. Apicella, Michael P. Jennings*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Neisseria gonorrhoeae has well-characterized oxidative stress defense systems that protect against oxidative killing in in vitro assays. In contrast, mutant strains of N. gonorrhoeae lacking oxidative stress defenses are identical to the wild type when tested in an ex vivo survival assay using human polymorphonuclear leukocytes.

Original languageEnglish
Pages (from-to)5269-5272
Number of pages4
JournalInfection and Immunity
Volume73
Issue number8
DOIs
StatePublished - Aug 2005
Externally publishedYes

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