Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay

Kate L. Seib; Mark P. Simons; Hsing Ju Wu; Alastair G. McEwan; William M. Nauseef; Michael A. Apicella; Michael P. Jennings

doi:10.1128/IAI.73.8.5269-5272.2005

Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay

Kate L. Seib, Mark P. Simons, Hsing Ju Wu, Alastair G. McEwan, William M. Nauseef, Michael A. Apicella, Michael P. Jennings^*

^*Corresponding author for this work

Infectious Disease Clinical Research Program (IDCRP)

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Neisseria gonorrhoeae has well-characterized oxidative stress defense systems that protect against oxidative killing in in vitro assays. In contrast, mutant strains of N. gonorrhoeae lacking oxidative stress defenses are identical to the wild type when tested in an ex vivo survival assay using human polymorphonuclear leukocytes.

Original language	English
Pages (from-to)	5269-5272
Number of pages	4
Journal	Infection and Immunity
Volume	73
Issue number	8
DOIs	https://doi.org/10.1128/IAI.73.8.5269-5272.2005
State	Published - Aug 2005

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10.1128/IAI.73.8.5269-5272.2005

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title = "Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay",

abstract = "Neisseria gonorrhoeae has well-characterized oxidative stress defense systems that protect against oxidative killing in in vitro assays. In contrast, mutant strains of N. gonorrhoeae lacking oxidative stress defenses are identical to the wild type when tested in an ex vivo survival assay using human polymorphonuclear leukocytes.",

author = "Seib, \{Kate L.\} and Simons, \{Mark P.\} and Wu, \{Hsing Ju\} and McEwan, \{Alastair G.\} and Nauseef, \{William M.\} and Apicella, \{Michael A.\} and Jennings, \{Michael P.\}",

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AU - Simons, Mark P.

AU - Wu, Hsing Ju

AU - McEwan, Alastair G.

AU - Nauseef, William M.

AU - Apicella, Michael A.

AU - Jennings, Michael P.

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AB - Neisseria gonorrhoeae has well-characterized oxidative stress defense systems that protect against oxidative killing in in vitro assays. In contrast, mutant strains of N. gonorrhoeae lacking oxidative stress defenses are identical to the wild type when tested in an ex vivo survival assay using human polymorphonuclear leukocytes.

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Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay

Abstract

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