Iodinated melatonin mimics melatonin action and reveals discrete binding sites in fetal brain

David R. Weaver; M. A.Aryan Namboodiri; Steven M. Reppert

doi:10.1016/0014-5793(88)80599-4

Iodinated melatonin mimics melatonin action and reveals discrete binding sites in fetal brain

David R. Weaver, M. A.Aryan Namboodiri, Steven M. Reppert^*

^*Corresponding author for this work

Anatomy, Physiology, and Genetics

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Abstract

Iodinated melatonin was used to study melatonin sites of action in brain. Iodomelatonin mimicked the effects of melatonin on reproductive development in Djungarian hamster fetuses. ¹²⁵I-melatonin injected into the dam was recovered from fetal brain. In vitro autoradiographic studies revealed a remarkably discrete distribution of competitive ¹²⁵I-melatonin-binding sites in the fetal brain, with binding in median eminence/arcuate nucleus area > suprachiasmatic nucleus > pineal gland ≫ anterior pituitary gland ≫ preoptic area. ¹²⁵I-melatonin promises to be a useful tool for understanding the sites and mechanism of action of melatonin.

Original language	English
Pages (from-to)	123-127
Number of pages	5
Journal	FEBS Letters
Volume	228
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(88)80599-4
State	Published - 8 Feb 1988

Keywords

(Hypothalamus, Suprachiasmatic nucleus)
Circadian rhythm
Melatonin
Photoperiodism
Reproduction

Access to Document

10.1016/0014-5793(88)80599-4

Cite this

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title = "Iodinated melatonin mimics melatonin action and reveals discrete binding sites in fetal brain",

abstract = "Iodinated melatonin was used to study melatonin sites of action in brain. Iodomelatonin mimicked the effects of melatonin on reproductive development in Djungarian hamster fetuses. 125I-melatonin injected into the dam was recovered from fetal brain. In vitro autoradiographic studies revealed a remarkably discrete distribution of competitive 125I-melatonin-binding sites in the fetal brain, with binding in median eminence/arcuate nucleus area > suprachiasmatic nucleus > pineal gland ≫ anterior pituitary gland ≫ preoptic area. 125I-melatonin promises to be a useful tool for understanding the sites and mechanism of action of melatonin.",

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AU - Weaver, David R.

AU - Namboodiri, M. A.Aryan

AU - Reppert, Steven M.

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Y1 - 1988/2/8

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AB - Iodinated melatonin was used to study melatonin sites of action in brain. Iodomelatonin mimicked the effects of melatonin on reproductive development in Djungarian hamster fetuses. 125I-melatonin injected into the dam was recovered from fetal brain. In vitro autoradiographic studies revealed a remarkably discrete distribution of competitive 125I-melatonin-binding sites in the fetal brain, with binding in median eminence/arcuate nucleus area > suprachiasmatic nucleus > pineal gland ≫ anterior pituitary gland ≫ preoptic area. 125I-melatonin promises to be a useful tool for understanding the sites and mechanism of action of melatonin.

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KW - Circadian rhythm

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KW - Photoperiodism

KW - Reproduction

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