Is Long COVID a State of Systemic Pericyte Disarray?

Olcay Y. Jones; Sencer Yeralan

doi:10.3390/jcm11030572

Is Long COVID a State of Systemic Pericyte Disarray?

Olcay Y. Jones^*, Sencer Yeralan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The most challenging aspect of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) or Long COVID remains for the discordance between the viral damage from acute infection in the recent past and susceptibility of Long COVID without clear evidence of post infectious inflammation or autoimmune reactions. In this communication we propose that disarray of pericytes plays a central role in emerge of Long COVID. We assume pericytes are agents with “Triple-A” qualities, i.e., analyze-adapt and advance, necessary for sustainability of host homeostasis. Based on this view, we further suggest Long COVID may provide a model system to integrate system theory and complex adaptive systems to explore a new class of maladies those are currently not well defined and with no remedies.

Original language	English
Article number	572
Journal	Journal of Clinical Medicine
Volume	11
Issue number	3
DOIs	https://doi.org/10.3390/jcm11030572
State	Published - 1 Feb 2022

Keywords

Complex dynamical systems
Emergent systems intelligence
Entropy
Long COVID
Pericyte
Triple-A

Access to Document

10.3390/jcm11030572

Cite this

@article{383d80accd6e41f0a4f71bb94f01ce89,

title = "Is Long COVID a State of Systemic Pericyte Disarray?",

abstract = "The most challenging aspect of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) or Long COVID remains for the discordance between the viral damage from acute infection in the recent past and susceptibility of Long COVID without clear evidence of post infectious inflammation or autoimmune reactions. In this communication we propose that disarray of pericytes plays a central role in emerge of Long COVID. We assume pericytes are agents with “Triple-A” qualities, i.e., analyze-adapt and advance, necessary for sustainability of host homeostasis. Based on this view, we further suggest Long COVID may provide a model system to integrate system theory and complex adaptive systems to explore a new class of maladies those are currently not well defined and with no remedies.",

keywords = "Complex dynamical systems, Emergent systems intelligence, Entropy, Long COVID, Pericyte, Triple-A",

author = "Jones, {Olcay Y.} and Sencer Yeralan",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = feb,

day = "1",

doi = "10.3390/jcm11030572",

language = "English",

volume = "11",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",