Jumping the barrier: Modeling drug penetration across the blood-brain barrier

Cody J. Peer; Cindy H. Chau; William D. Figg

doi:10.1158/1078-0432.CCR-17-2741

Jumping the barrier: Modeling drug penetration across the blood-brain barrier

Cody J. Peer, Cindy H. Chau, William D. Figg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Determining the penetration of drugs across the bloodbrain barrier is a significant challenge in central nervous system drug development. The use of a mechanistic physiologically based pharmacokinetic model can predict drug exposures in the brain without needing in situ drug measurements.

Original language	English
Pages (from-to)	7437-7439
Number of pages	3
Journal	Clinical Cancer Research
Volume	23
Issue number	24
DOIs	https://doi.org/10.1158/1078-0432.CCR-17-2741
State	Published - 15 Dec 2017
Externally published	Yes

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title = "Jumping the barrier: Modeling drug penetration across the blood-brain barrier",

abstract = "Determining the penetration of drugs across the bloodbrain barrier is a significant challenge in central nervous system drug development. The use of a mechanistic physiologically based pharmacokinetic model can predict drug exposures in the brain without needing in situ drug measurements.",

author = "Peer, {Cody J.} and Chau, {Cindy H.} and Figg, {William D.}",

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JO - Clinical Cancer Research

JF - Clinical Cancer Research

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Jumping the barrier: Modeling drug penetration across the blood-brain barrier

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