Abstract
We have studied the properties of kainic acid receptor-activated channels using domoic acid as an agonist. Similarities of the electrophysiological, pharmacological and noise properties of domoic acid and kainic acid-evoked currents confirm that domoate is a potent and specific agonist of the kainate receptor. Single-channel properties of domoic acid-evoked currents were directly determined from outside-out membrane patches for the first time, and results were compared with those obtained by fluctuation analysis of macroscopic currents. Small conductance cationic-selective channels of ≈4 pS and a mean open time of 2 to 3 ms were detected using both methods.
| Original language | English |
|---|---|
| Pages (from-to) | 63-68 |
| Number of pages | 6 |
| Journal | European Biophysics Journal |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 1990 |
Keywords
- Domoic acid
- Excitatory aminoacids
- Kainic acid
- Patch-clamp
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