KCNQ1 D673N variant causes loss of adrenergic-induced cardiac action potential shortening

Naheed Fatima; Lydia Hellwig; Michael Klein; Cecelia C. Mangione; Princess Nwachukwu; Joshua Salzer; Clifton L. Dalgard; Joaquin Villar; Mark C. Haigney; Thomas Flagg

doi:10.1016/j.hrcr.2026.03.020

KCNQ1 D673N variant causes loss of adrenergic-induced cardiac action potential shortening

Naheed Fatima
, Lydia Hellwig
, Michael Klein
, Cecelia C. Mangione
, Princess Nwachukwu
, Joshua Salzer
, Clifton L. Dalgard
, Joaquin Villar
, Mark C. Haigney
, Thomas Flagg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	HeartRhythm Case Reports
DOIs	https://doi.org/10.1016/j.hrcr.2026.03.020
State	Published - 2026

Keywords

Genetic interpretation
iPSC
LQTS1
Sudden cardiac death
Variant of uncertain significance

Access to Document

10.1016/j.hrcr.2026.03.020

Cite this

@article{8e3d82eebd034e63b1b4b0ab306d607a,

title = "KCNQ1 D673N variant causes loss of adrenergic-induced cardiac action potential shortening",

keywords = "Genetic interpretation, iPSC, LQTS1, Sudden cardiac death, Variant of uncertain significance",

author = "Naheed Fatima and Lydia Hellwig and Michael Klein and Mangione, \{Cecelia C.\} and Princess Nwachukwu and Joshua Salzer and Dalgard, \{Clifton L.\} and Joaquin Villar and Haigney, \{Mark C.\} and Thomas Flagg",

year = "2026",

doi = "10.1016/j.hrcr.2026.03.020",

language = "English",

journal = "HeartRhythm Case Reports",

issn = "2214-0271",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - KCNQ1 D673N variant causes loss of adrenergic-induced cardiac action potential shortening

AU - Fatima, Naheed

AU - Hellwig, Lydia

AU - Klein, Michael

AU - Mangione, Cecelia C.

AU - Nwachukwu, Princess

AU - Salzer, Joshua

AU - Dalgard, Clifton L.

AU - Villar, Joaquin

AU - Haigney, Mark C.

AU - Flagg, Thomas

PY - 2026

Y1 - 2026

KW - Genetic interpretation

KW - iPSC

KW - LQTS1

KW - Sudden cardiac death

KW - Variant of uncertain significance

UR - https://www.scopus.com/pages/publications/105036430438

U2 - 10.1016/j.hrcr.2026.03.020

DO - 10.1016/j.hrcr.2026.03.020

M3 - Article

AN - SCOPUS:105036430438

SN - 2214-0271

JO - HeartRhythm Case Reports

JF - HeartRhythm Case Reports

ER -