KCNQ1 D673N variant causes loss of adrenergic-induced cardiac action potential shortening

Naheed Fatima; Lydia D. Hellwig; Michael G. Klein; Cecelia C. Mangione; Princess Nwachukwu; Joshua Salzer; Clifton L. Dalgard; Joaquin Villar; Mark C. Haigney; Thomas P. Flagg

doi:10.1016/j.hrcr.2026.03.020

KCNQ1 D673N variant causes loss of adrenergic-induced cardiac action potential shortening

Naheed Fatima
, Lydia D. Hellwig
, Michael G. Klein
, Cecelia C. Mangione
, Princess Nwachukwu
, Joshua Salzer
, Clifton L. Dalgard
, Joaquin Villar
, Mark C. Haigney
, Thomas P. Flagg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	802-809
Number of pages	8
Journal	HeartRhythm Case Reports
Volume	12
Issue number	7
DOIs	https://doi.org/10.1016/j.hrcr.2026.03.020
State	Published - 2026

Keywords

Genetic interpretation
LQTS1
Sudden cardiac death
Variant of uncertain significance
iPSC

Access to Document

10.1016/j.hrcr.2026.03.020

Cite this

@article{8e3d82eebd034e63b1b4b0ab306d607a,

title = "KCNQ1 D673N variant causes loss of adrenergic-induced cardiac action potential shortening",

keywords = "Genetic interpretation, LQTS1, Sudden cardiac death, Variant of uncertain significance, iPSC",

author = "Naheed Fatima and Hellwig, \{Lydia D.\} and Klein, \{Michael G.\} and Mangione, \{Cecelia C.\} and Princess Nwachukwu and Joshua Salzer and Dalgard, \{Clifton L.\} and Joaquin Villar and Haigney, \{Mark C.\} and Flagg, \{Thomas P.\}",

year = "2026",

doi = "10.1016/j.hrcr.2026.03.020",

language = "English",

volume = "12",

pages = "802--809",

journal = "HeartRhythm Case Reports",

issn = "2214-0271",

publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - KCNQ1 D673N variant causes loss of adrenergic-induced cardiac action potential shortening

AU - Fatima, Naheed

AU - Hellwig, Lydia D.

AU - Klein, Michael G.

AU - Mangione, Cecelia C.

AU - Nwachukwu, Princess

AU - Salzer, Joshua

AU - Dalgard, Clifton L.

AU - Villar, Joaquin

AU - Haigney, Mark C.

AU - Flagg, Thomas P.

PY - 2026

Y1 - 2026

KW - Genetic interpretation

KW - LQTS1

KW - Sudden cardiac death

KW - Variant of uncertain significance

KW - iPSC

UR - https://www.scopus.com/pages/publications/105036430438

U2 - 10.1016/j.hrcr.2026.03.020

DO - 10.1016/j.hrcr.2026.03.020

M3 - Article

AN - SCOPUS:105036430438

SN - 2214-0271

VL - 12

SP - 802

EP - 809

JO - HeartRhythm Case Reports

JF - HeartRhythm Case Reports

IS - 7

ER -