TY - JOUR
T1 - Les lymphocytes T régulateurs et les lymphocytes Th17
T2 - Fonctions physiologiques et pathologiques
AU - Corvaisier-Chiron, Murielle
AU - Beauvillain, Céline
AU - Hughes, Jeremy
AU - Jefferson, Ashley
AU - Raynaud De Mauverger, E.
AU - Fernandez, Gabriel
AU - Lowy, I.
AU - Molrine, D.
AU - Vingert, B.
AU - Perez-Patrigeon, S.
AU - Jeannin, P.
AU - Bourne, Y.
AU - Radic, Z.
AU - Aráoz, R.
AU - Weeks, A.
AU - Alia, G.
AU - Clarke, R.
AU - Peden, J.
AU - Steidl, C.
AU - Lee, T.
AU - Shah, S.
AU - Liang, S.
AU - Wang, H.
AU - Newell, K.
AU - Asare, A.
AU - Kirk, A.
AU - Studebaker, A.
AU - Kreofsky, C.
AU - Pierson, C.
AU - Lam, C.
AU - Yoo, T.
AU - Hiner, B.
PY - 2010
Y1 - 2010
N2 - Over two decades ago, CD4+ T cells were classified into various T cell subsets. Each subset is characterised by its specific cytokine pattern and effector functions in the immune response. This classification has long been confined to two subsets of helper T cells called Th1 and Th2 cells. Recently, new CD4+ T cell populations have been describe, including natural and inducible regulatory T cells and the proinflammatory Th17 cells. The discovery of these new populations provided a better understanding of the pathophysiology of various diseases, including chronic inflammatory disorders including some of autoimmune diseases, cancers and chronic infections. In this review, the generation of regulatory T cells and Th17 cells, the mechanisms used by these T cells to maintain the physiological balance between inflammatory and immunosuppressive immune responses, and their implication in physiopathology of various diseases will be discussed.
AB - Over two decades ago, CD4+ T cells were classified into various T cell subsets. Each subset is characterised by its specific cytokine pattern and effector functions in the immune response. This classification has long been confined to two subsets of helper T cells called Th1 and Th2 cells. Recently, new CD4+ T cell populations have been describe, including natural and inducible regulatory T cells and the proinflammatory Th17 cells. The discovery of these new populations provided a better understanding of the pathophysiology of various diseases, including chronic inflammatory disorders including some of autoimmune diseases, cancers and chronic infections. In this review, the generation of regulatory T cells and Th17 cells, the mechanisms used by these T cells to maintain the physiological balance between inflammatory and immunosuppressive immune responses, and their implication in physiopathology of various diseases will be discussed.
KW - Immune response
KW - Th17 cells
KW - auto-immune diseases
KW - cancers
KW - infectious diseases
KW - regulatory T cells
UR - http://www.scopus.com/inward/record.url?scp=77955011086&partnerID=8YFLogxK
U2 - 10.1016/s1773-035x(10)70607-9
DO - 10.1016/s1773-035x(10)70607-9
M3 - Article
AN - SCOPUS:77955011086
SN - 1773-035X
VL - 2010
SP - 31
EP - 40
JO - Revue Francophone des Laboratoires
JF - Revue Francophone des Laboratoires
IS - 424
ER -