@article{b92efcb53fe24daa8ea0404a9205ce5e,
title = "Lipidomic signatures align with inflammatory patterns and outcomes in critical illness",
abstract = "Alterations in lipid metabolism have the potential to be markers as well as drivers of pathobiology of acute critical illness. Here, we took advantage of the temporal precision offered by trauma as a common cause of critical illness to identify the dynamic patterns in the circulating lipidome in critically ill humans. The major findings include an early loss of all classes of circulating lipids followed by a delayed and selective lipogenesis in patients destined to remain critically ill. The previously reported survival benefit of early thawed plasma administration was associated with preserved lipid levels that related to favorable changes in coagulation and inflammation biomarkers in causal modelling. Phosphatidylethanolamines (PE) were elevated in patients with persistent critical illness and PE levels were prognostic for worse outcomes not only in trauma but also severe COVID-19 patients. Here we show selective rise in systemic PE as a common prognostic feature of critical illness.",
author = "{PAMPer study group} and Junru Wu and Anthony Cyr and Gruen, {Danielle S.} and Lovelace, {Tyler C.} and Benos, {Panayiotis V.} and Jishnu Das and Kar, {Upendra K.} and Tianmeng Chen and Guyette, {Francis X.} and Yazer, {Mark H.} and Daley, {Brian J.} and Miller, {Richard S.} and Harbrecht, {Brian G.} and Claridge, {Jeffrey A.} and Phelan, {Herb A.} and Zuckerbraun, {Brian S.} and Neal, {Matthew D.} and Johansson, {P{\"a}r I.} and Jakob Stensballe and Namas, {Rami A.} and Yoram Vodovotz and Sperry, {Jason L.} and Billiar, {Timothy R.} and Zenati, {Mazen S.} and Brown, {Joshua B.} and Triulzi, {Darrell J.} and Young, {Barbara J.Early} and Adams, {Peter W.} and Alarcon, {Louis H.} and Callaway, {Clifton W.} and Forsythe, {Raquel M.} and Yealy, {Donald M.} and Peitzman, {Andrew B.} and Buck, {Meghan L.} and Ryman, {Ashley M.} and Gimbel, {Elizabeth A.} and Gilchrist, {Erin G.} and Meghan Buhay and Chang, {Chung Chou H.} and Talisa, {Victor B.} and Tianyuan Xu and Kyle Kalloway and Andrew Yates and Susan Rawn and Jenkins, {Judith M.} and Trachtenberg, {Laura S.} and Eden, {Randi K.} and Joanne Fraifogl and Craig Bates and Christina Howard",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s41467-022-34420-4",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
number = "1",
}