Liquid Tissue: proteomic profiling of formalin-fixed tissues.

Da Rue A. Prieto; Brian L. Hood; Marlene M. Darfler; Thomas G. Guiel; David A. Lucas; Thomas P. Conrads; Timothy D. Veenstra; David B. Krizman

Liquid Tissue: proteomic profiling of formalin-fixed tissues.

Da Rue A. Prieto^*, Brian L. Hood, Marlene M. Darfler, Thomas G. Guiel, David A. Lucas, Thomas P. Conrads, Timothy D. Veenstra, David B. Krizman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

Identification and quantitation of candidate biomarker proteins in large numbers of individual tissues is required to validate specific proteins, or panels of proteins, for clinical use as diagnostic, prognostic, toxicological, or therapeutic markers. Mass spectrometry (MS) provides an exciting analytical methodology for this purpose. Liquid Tissue MS protein preparation allows researchers to utilize the vast, already existing, collections offormalin-fixed paraffin-embedded (FFPE) tissues for the procurement of peptides and the analysis across a variety of MS platforms.

Original language	English
Pages (from-to)	32-35
Number of pages	4
Journal	BioTechniques
Volume	Suppl
State	Published - Jun 2005
Externally published	Yes

Cite this

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title = "Liquid Tissue: proteomic profiling of formalin-fixed tissues.",

abstract = "Identification and quantitation of candidate biomarker proteins in large numbers of individual tissues is required to validate specific proteins, or panels of proteins, for clinical use as diagnostic, prognostic, toxicological, or therapeutic markers. Mass spectrometry (MS) provides an exciting analytical methodology for this purpose. Liquid Tissue MS protein preparation allows researchers to utilize the vast, already existing, collections offormalin-fixed paraffin-embedded (FFPE) tissues for the procurement of peptides and the analysis across a variety of MS platforms.",

author = "Prieto, {Da Rue A.} and Hood, {Brian L.} and Darfler, {Marlene M.} and Guiel, {Thomas G.} and Lucas, {David A.} and Conrads, {Thomas P.} and Veenstra, {Timothy D.} and Krizman, {David B.}",

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T2 - proteomic profiling of formalin-fixed tissues.

AU - Prieto, Da Rue A.

AU - Hood, Brian L.

AU - Darfler, Marlene M.

AU - Guiel, Thomas G.

AU - Lucas, David A.

AU - Conrads, Thomas P.

AU - Veenstra, Timothy D.

AU - Krizman, David B.

PY - 2005/6

Y1 - 2005/6

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AB - Identification and quantitation of candidate biomarker proteins in large numbers of individual tissues is required to validate specific proteins, or panels of proteins, for clinical use as diagnostic, prognostic, toxicological, or therapeutic markers. Mass spectrometry (MS) provides an exciting analytical methodology for this purpose. Liquid Tissue MS protein preparation allows researchers to utilize the vast, already existing, collections offormalin-fixed paraffin-embedded (FFPE) tissues for the procurement of peptides and the analysis across a variety of MS platforms.

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ER -

Liquid Tissue: proteomic profiling of formalin-fixed tissues.

Abstract

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