Liquid Tissue: proteomic profiling of formalin-fixed tissues.

Da Rue A. Prieto*, Brian L. Hood, Marlene M. Darfler, Thomas G. Guiel, David A. Lucas, Thomas P. Conrads, Timothy D. Veenstra, David B. Krizman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

Identification and quantitation of candidate biomarker proteins in large numbers of individual tissues is required to validate specific proteins, or panels of proteins, for clinical use as diagnostic, prognostic, toxicological, or therapeutic markers. Mass spectrometry (MS) provides an exciting analytical methodology for this purpose. Liquid Tissue MS protein preparation allows researchers to utilize the vast, already existing, collections offormalin-fixed paraffin-embedded (FFPE) tissues for the procurement of peptides and the analysis across a variety of MS platforms.

Original languageEnglish
Pages (from-to)32-35
Number of pages4
JournalBioTechniques
VolumeSuppl
StatePublished - Jun 2005
Externally publishedYes

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