TY - JOUR
T1 - List of lists-annotated (LOLA)
T2 - A database for annotation and comparison of published microarray gene lists
AU - Cahan, Patrick
AU - Ahmad, Amera M.
AU - Burke, Harry
AU - Fu, Sidney
AU - Lai, Yinglei
AU - Florea, Liliana
AU - Dharker, Nachiket
AU - Kobrinski, Todd
AU - Kale, Prachee
AU - McCaffrey, Timothy A.
N1 - Funding Information:
The authors are grateful for the financial support of the NIH/National Institutes on Aging (AG12712), and The Catherine Birch McCormick Genomic Center.
PY - 2005/10/24
Y1 - 2005/10/24
N2 - Microarray profiling of RNA expression is a powerful tool that generates large lists of transcripts that are potentially relevant to a disease or treatment. However, because the lists of changed transcripts are embedded in figures and tables, they are typically inaccessible for search engines. Due to differences in gene nomenclatures, the lists are difficult to compare between studies. LOLA (Lists of Lists Annotated) is an internet-based database for comparing gene lists from microarray studies or other genomic-scale methods. It serves as a common platform to compare and reannotate heterogeneous gene lists from different microarray platforms or different genomic methodologies such as serial analysis of gene expression (SAGE) or proteomics. LOLA (www.lola.gwu.edu) provides researchers with a means to store, annotate, and compare gene lists produced from different studies or different analyses of the same study. It is especially useful in identifying potentially "high interest" genes which are reported as significant across multiple studies and species. Its application to the fields of stem cell, cancer, and aging research is demonstrated by comparing published papers.
AB - Microarray profiling of RNA expression is a powerful tool that generates large lists of transcripts that are potentially relevant to a disease or treatment. However, because the lists of changed transcripts are embedded in figures and tables, they are typically inaccessible for search engines. Due to differences in gene nomenclatures, the lists are difficult to compare between studies. LOLA (Lists of Lists Annotated) is an internet-based database for comparing gene lists from microarray studies or other genomic-scale methods. It serves as a common platform to compare and reannotate heterogeneous gene lists from different microarray platforms or different genomic methodologies such as serial analysis of gene expression (SAGE) or proteomics. LOLA (www.lola.gwu.edu) provides researchers with a means to store, annotate, and compare gene lists produced from different studies or different analyses of the same study. It is especially useful in identifying potentially "high interest" genes which are reported as significant across multiple studies and species. Its application to the fields of stem cell, cancer, and aging research is demonstrated by comparing published papers.
KW - Aging
KW - Bioinformatics
KW - Expression profiling
KW - Gene annotation
KW - Gene expression
KW - Microarray
KW - Transcript profiling
UR - http://www.scopus.com/inward/record.url?scp=26444563353&partnerID=8YFLogxK
U2 - 10.1016/j.gene.2005.07.008
DO - 10.1016/j.gene.2005.07.008
M3 - Article
C2 - 16140476
AN - SCOPUS:26444563353
SN - 0378-1119
VL - 360
SP - 78
EP - 82
JO - Gene
JF - Gene
IS - 1
ER -