Listeria monocytogenes infections in patients with AIDS: Report of five cases and review

C. F. Decker, G. L. Simon, R. A. DiGioia, C. U. Tuazon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Five patients with AIDS and Listeria monocytogenes infection (three cases of bacteremia and two of meningitis) are reviewed. Four patients had prior or concurrent gastrointestinal illness. Two patients received corticosteroids. A 7- to 21-day course of ampicillin was administered with or without a 7- to 14-day course of gentamicin. This regimen was effective, with no evidence of relapse 7-8 months after therapy was discontinued. The relative infrequency of infection with L. monocytogenes in AIDS patients is unexpected. Tumor necrosis factor (TNF) appears to be essential in the inhibition of Listeria in vivo. Elevated levels of TNF in AIDS patients may be protective against listeriosis and thus help explain the low prevalence of listerial infection in this population. Nonetheless, although L. monocytogenes is an uncommon cause of illness in patients infected with the human immunodeficiency virus, it cannot be dismissed as a cause of undefined meningitis or sepsis.

Original languageEnglish
Pages (from-to)413-417
Number of pages5
JournalReviews of Infectious Diseases
Issue number3
StatePublished - 1991


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