Local alendronate increases fixation of implants inserted with bone compaction: 12-week canine study

Thomas Jakobsen*, Søren Kold, Joan E. Bechtold, Brian Elmengaard, Kjeld Søballe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Bone compaction has been shown to increase initial implant fixation. Furthermore, bone compaction creates a peri-implant zone of autograft that exerts osteoconductive properties. We have previously shown that locally applied bisphosphonate (alendronate) at 4-week observation can preserve the autograft generated by bone compaction. We now investigate whether the increased amount of autograft, seen at 4 weeks, can increase implant osseointegration and biomechanical fixation. Porous-coated titanium implants were bilaterally inserted with bone compaction into the proximal part of tibia of 10 dogs. On the right side, local bisphosphonate was injected into the bone cavity prior to bone compaction immediately prior to implant insertion. On the left side, saline was used as control. Observation period was 12 weeks. Locally applied bisphosphonate significantly increased biomechanical implant fixation (approximately twofold), bone-to-implant contact (1.2-fold), and peri-implant bone volume fraction (2.3-fold). This study indicates that local alendronate treatment can increase early implant osseointegration and biomechanical fixation of implants inserted by use of bone compaction. Long term effects remain unknown.

Original languageEnglish
Pages (from-to)432-441
Number of pages10
JournalJournal of Orthopaedic Research
Issue number4
StatePublished - Apr 2007
Externally publishedYes


  • Bone compaction
  • Canines
  • Implants


Dive into the research topics of 'Local alendronate increases fixation of implants inserted with bone compaction: 12-week canine study'. Together they form a unique fingerprint.

Cite this