Local dynamics and viscoelastic properties of cell biological systems

Yiider Tseng; Thomas P. Kole; Ssu Hsien J. Lee; Denis Wirtz

doi:10.1016/S1359-0294(02)00050-X

Local dynamics and viscoelastic properties of cell biological systems

Yiider Tseng, Thomas P. Kole, Ssu Hsien J. Lee, Denis Wirtz^*

^*Corresponding author for this work

Surgery

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33 Scopus citations

Abstract

How the cytoskeleton, a heterogeneous network of dynamic filamentous proteins, provides the cell with structural support is not well understood. Particle-tracking methods, which probe local mechanical properties, are well suited to test existing hypotheses derived from in vitro models of reconstituted cytoskeleton networks. This paper reviews recent applications of single- and multiple-particle tracking microrheology, with an emphasis on the semiflexible polymer F-actin and the flexible polymer keratin, two ubiquitous proteins of the cytoskeleton. Extensive knowledge of the properties of these polymers allows a rigorous comparison between theory and experiments to a level rarely matched by synthetic polymers.

Original language	English
Pages (from-to)	210-217
Number of pages	8
Journal	Current Opinion in Colloid and Interface Science
Volume	7
Issue number	3-4
DOIs	https://doi.org/10.1016/S1359-0294(02)00050-X
State	Published - Aug 2002

Keywords

Cytoskeleton
F-Actin
Keratin
Microrheology
Particle tracking

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10.1016/S1359-0294(02)00050-X

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title = "Local dynamics and viscoelastic properties of cell biological systems",

abstract = "How the cytoskeleton, a heterogeneous network of dynamic filamentous proteins, provides the cell with structural support is not well understood. Particle-tracking methods, which probe local mechanical properties, are well suited to test existing hypotheses derived from in vitro models of reconstituted cytoskeleton networks. This paper reviews recent applications of single- and multiple-particle tracking microrheology, with an emphasis on the semiflexible polymer F-actin and the flexible polymer keratin, two ubiquitous proteins of the cytoskeleton. Extensive knowledge of the properties of these polymers allows a rigorous comparison between theory and experiments to a level rarely matched by synthetic polymers.",

keywords = "Cytoskeleton, F-Actin, Keratin, Microrheology, Particle tracking",

author = "Yiider Tseng and Kole, {Thomas P.} and Lee, {Ssu Hsien J.} and Denis Wirtz",

note = "Funding Information: We thank Gary Borisy for Fig. 1 b–d. This research is supported in part by the NSF and the ACS-PRF.",

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T1 - Local dynamics and viscoelastic properties of cell biological systems

AU - Tseng, Yiider

AU - Kole, Thomas P.

AU - Lee, Ssu Hsien J.

AU - Wirtz, Denis

N1 - Funding Information: We thank Gary Borisy for Fig. 1 b–d. This research is supported in part by the NSF and the ACS-PRF.

PY - 2002/8

Y1 - 2002/8

N2 - How the cytoskeleton, a heterogeneous network of dynamic filamentous proteins, provides the cell with structural support is not well understood. Particle-tracking methods, which probe local mechanical properties, are well suited to test existing hypotheses derived from in vitro models of reconstituted cytoskeleton networks. This paper reviews recent applications of single- and multiple-particle tracking microrheology, with an emphasis on the semiflexible polymer F-actin and the flexible polymer keratin, two ubiquitous proteins of the cytoskeleton. Extensive knowledge of the properties of these polymers allows a rigorous comparison between theory and experiments to a level rarely matched by synthetic polymers.

AB - How the cytoskeleton, a heterogeneous network of dynamic filamentous proteins, provides the cell with structural support is not well understood. Particle-tracking methods, which probe local mechanical properties, are well suited to test existing hypotheses derived from in vitro models of reconstituted cytoskeleton networks. This paper reviews recent applications of single- and multiple-particle tracking microrheology, with an emphasis on the semiflexible polymer F-actin and the flexible polymer keratin, two ubiquitous proteins of the cytoskeleton. Extensive knowledge of the properties of these polymers allows a rigorous comparison between theory and experiments to a level rarely matched by synthetic polymers.

KW - Cytoskeleton

KW - F-Actin

KW - Keratin

KW - Microrheology

KW - Particle tracking

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DO - 10.1016/S1359-0294(02)00050-X

M3 - Article

AN - SCOPUS:0036685881

SN - 1359-0294

VL - 7

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EP - 217

JO - Current Opinion in Colloid and Interface Science

JF - Current Opinion in Colloid and Interface Science

IS - 3-4

ER -

Local dynamics and viscoelastic properties of cell biological systems

Abstract

Keywords

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