TY - JOUR
T1 - Long-term durability of immune responses after hepatitis A vaccination among HIV-infected adults
AU - Crum-Cianflone, Nancy F.
AU - Wilkins, Kenneth
AU - Lee, Andrew W.
AU - Grosso, Anthony
AU - Landrum, Michael L.
AU - Weintrob, Amy
AU - Ganesan, Anuradha
AU - Maguire, Jason
AU - Klopfer, Stephanie
AU - Brandt, Carolyn
AU - Bradley, William P.
AU - Wallace, Mark R.
AU - Agan, Brian K.
AU - Banks, Susan
AU - Bavaro, Mary
AU - Chun, Helen
AU - Decker, Cathy
AU - Eggleston, Conner
AU - Fraser, Susan
AU - Hairston, Heather
AU - Hartzell, Joshua
AU - Johnson, Arthur
AU - Kortepeter, Mark
AU - Lalani, Tahaniyat
AU - Lifson, Alan
AU - Linfesty, Michelle
AU - Macalino, Grace
AU - Merritt, Scott
AU - Nagaraj, Barbara
AU - O'Connell, Robert
AU - Okulicz, Jason
AU - Peel, Sheila
AU - Polis, Michael
AU - Powers, John
AU - Tasker, Sybil
AU - Whitman, Timothy
AU - Wortmann, Glenn
AU - Zapor, Michael
N1 - Funding Information:
This work was supported by the Infectious Disease Clinical Research Program, a Department of Defense program executed through the Uniformed Services University of the Health Sciences (IDCRP-000-11); and the National Institute of Allergy and Infectious Diseases, National Institutes of Health (Inter-Agency Agreement Y1-AI-5072).
PY - 2011/6/15
Y1 - 2011/6/15
N2 - Background. Vaccination provides long-term immunity to hepatitis A virus (HAV) among the general population, but there are no such data regarding vaccine durability among human immunodeficiency virus (HIV) - infected adults. Methods. We retrospectively studied HIV-infected adults who had received 2 doses of HAV vaccine. We analyzed blood specimens taken at 1 year, 3 years, and, when available, 6-10 years postvaccination. HAV immunoglobulin G (IgG) values of ≥10 mIU/mL were considered seropositive. Results. We evaluated specimens from 130 HIV-infected adults with a median age of 35 years and a median CD4 cell count of 461 cells/mm3 at or before time of vaccination. Of these, 49% had an HIV RNA load <1000 copies/mL. Initial vaccine responses were achieved in 89% of HIV-infected adults (95% confidence interval [CI], 83%-94%), compared with 100% (95% CI, 99%-100%) of historical HIV-uninfected adults. Among initial HIV-infected responders with available specimens, 90% (104 of 116; 95% CI, 83%-95%) remained seropositive at 3 years and 85% (63 of 74; 95% CI, 75%-92%) at 6-10 years. Geometric mean concentrations (GMCs) among HIV-infected adults were 154, 111, and 64 mIU/mL at 1, 3, and 6-10 years, respectively, compared with 1734, 687, and 684 mIU/mL among HIV-uninfected persons. Higher GMCs over time among HIV-infected adults were associated with lower log10 HIV RNA levels (β = 2.12, P = .04). Conclusions. Most adults with well-controlled HIV infections had durable seropositive responses up to 6-10 years after HAV vaccination. Suppressed HIV RNA levels are associated with durable HAV responses.
AB - Background. Vaccination provides long-term immunity to hepatitis A virus (HAV) among the general population, but there are no such data regarding vaccine durability among human immunodeficiency virus (HIV) - infected adults. Methods. We retrospectively studied HIV-infected adults who had received 2 doses of HAV vaccine. We analyzed blood specimens taken at 1 year, 3 years, and, when available, 6-10 years postvaccination. HAV immunoglobulin G (IgG) values of ≥10 mIU/mL were considered seropositive. Results. We evaluated specimens from 130 HIV-infected adults with a median age of 35 years and a median CD4 cell count of 461 cells/mm3 at or before time of vaccination. Of these, 49% had an HIV RNA load <1000 copies/mL. Initial vaccine responses were achieved in 89% of HIV-infected adults (95% confidence interval [CI], 83%-94%), compared with 100% (95% CI, 99%-100%) of historical HIV-uninfected adults. Among initial HIV-infected responders with available specimens, 90% (104 of 116; 95% CI, 83%-95%) remained seropositive at 3 years and 85% (63 of 74; 95% CI, 75%-92%) at 6-10 years. Geometric mean concentrations (GMCs) among HIV-infected adults were 154, 111, and 64 mIU/mL at 1, 3, and 6-10 years, respectively, compared with 1734, 687, and 684 mIU/mL among HIV-uninfected persons. Higher GMCs over time among HIV-infected adults were associated with lower log10 HIV RNA levels (β = 2.12, P = .04). Conclusions. Most adults with well-controlled HIV infections had durable seropositive responses up to 6-10 years after HAV vaccination. Suppressed HIV RNA levels are associated with durable HAV responses.
UR - http://www.scopus.com/inward/record.url?scp=79957518895&partnerID=8YFLogxK
U2 - 10.1093/infdis/jir180
DO - 10.1093/infdis/jir180
M3 - Article
C2 - 21606540
AN - SCOPUS:79957518895
SN - 0022-1899
VL - 203
SP - 1815
EP - 1823
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 12
ER -