Long-term durability of immune responses after hepatitis A vaccination among HIV-infected adults

Nancy F. Crum-Cianflone, Kenneth Wilkins, Andrew W. Lee, Anthony Grosso, Michael L. Landrum, Amy Weintrob, Anuradha Ganesan, Jason Maguire, Stephanie Klopfer, Carolyn Brandt, William P. Bradley, Mark R. Wallace, Brian K. Agan, Susan Banks, Mary Bavaro, Helen Chun, Cathy Decker, Conner Eggleston, Susan Fraser, Heather HairstonJoshua Hartzell, Arthur Johnson, Mark Kortepeter, Tahaniyat Lalani, Alan Lifson, Michelle Linfesty, Grace Macalino, Scott Merritt, Barbara Nagaraj, Robert O'Connell, Jason Okulicz, Sheila Peel, Michael Polis, John Powers, Sybil Tasker, Timothy Whitman, Glenn Wortmann, Michael Zapor

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Background. Vaccination provides long-term immunity to hepatitis A virus (HAV) among the general population, but there are no such data regarding vaccine durability among human immunodeficiency virus (HIV) - infected adults. Methods. We retrospectively studied HIV-infected adults who had received 2 doses of HAV vaccine. We analyzed blood specimens taken at 1 year, 3 years, and, when available, 6-10 years postvaccination. HAV immunoglobulin G (IgG) values of ≥10 mIU/mL were considered seropositive. Results. We evaluated specimens from 130 HIV-infected adults with a median age of 35 years and a median CD4 cell count of 461 cells/mm3 at or before time of vaccination. Of these, 49% had an HIV RNA load <1000 copies/mL. Initial vaccine responses were achieved in 89% of HIV-infected adults (95% confidence interval [CI], 83%-94%), compared with 100% (95% CI, 99%-100%) of historical HIV-uninfected adults. Among initial HIV-infected responders with available specimens, 90% (104 of 116; 95% CI, 83%-95%) remained seropositive at 3 years and 85% (63 of 74; 95% CI, 75%-92%) at 6-10 years. Geometric mean concentrations (GMCs) among HIV-infected adults were 154, 111, and 64 mIU/mL at 1, 3, and 6-10 years, respectively, compared with 1734, 687, and 684 mIU/mL among HIV-uninfected persons. Higher GMCs over time among HIV-infected adults were associated with lower log10 HIV RNA levels (β = 2.12, P = .04). Conclusions. Most adults with well-controlled HIV infections had durable seropositive responses up to 6-10 years after HAV vaccination. Suppressed HIV RNA levels are associated with durable HAV responses.

Original languageEnglish
Pages (from-to)1815-1823
Number of pages9
JournalJournal of Infectious Diseases
Issue number12
StatePublished - 15 Jun 2011


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